New enzymes for cell surface modification: Towards universal blood and improved organ transplants
September 15-19, 2019
Mammalian cell surfaces are coated in specific sugar structures, many of which function as antigens and are involved in cellular recognition. Important examples are the oligosaccharide A, B, and H antigens present on red blood cells that differentiate the A, B and O blood types. Enzymatic cleavage of the GalNAc and Gal residues from the cell surface would allow conversion of A and B red blood cells, respectively, to O type. Since Type O blood can be universally donated to patients with the same Rh factor, access to efficient enzymes would greatly broaden and simplify blood supply. We have sought such enzymes in metagenomic libraries derived from the human gut microbiome.
Please click Additional Files below to see the full abstract.
Stephen Withers, Peter Rahfeld, Lyann Sim, Haisle Moon, and Jayachandran Kizhakkedathu, "New enzymes for cell surface modification: Towards universal blood and improved organ transplants" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/119