Promiscuity, serendipity and metabolic innovation

Conference Dates

September 15-19, 2019


Bioinformatic evidence suggests that metabolic pathways have evolved by “patchwork” recruitment of enzymes that have a promiscuous ability to catalyze a newly important reaction. However, we cannot explain why certain pathways arose rather than the thousands of other possibilities. Further, we have little insight into the process by which novel pathways were patched together and flux was improved via mutations.

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