Promiscuity, serendipity and metabolic innovation
September 15-19, 2019
Bioinformatic evidence suggests that metabolic pathways have evolved by “patchwork” recruitment of enzymes that have a promiscuous ability to catalyze a newly important reaction. However, we cannot explain why certain pathways arose rather than the thousands of other possibilities. Further, we have little insight into the process by which novel pathways were patched together and flux was improved via mutations.
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Shelley Copley, "Promiscuity, serendipity and metabolic innovation" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/140