Engineering of halohydrin hydrogen-halide-lyase (H-lyase) for efficient L-carnitine production
September 15-19, 2019
L-carnitine is a beta-hydroxy carboxylic acid known as a dietary supplement with the effect of fat-burning or anti-fatigue. Although several production processes of L-carnitine are proposed including fermentation, chiral resolution or asymmetric synthesis, there are disadvantages with each from the point of view of yield, side-reactions or productivity. We have engaged in technology development of efficient enzymatic production of various chemicals for years, represented with the world’s first industrialized bioprocess for acrylamide. Leveraging our specialty including proprietary nitrile-related enzymes and associated technologies, we attempted to develop a further efficient production process of L-carnitine (Figure 1).
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Takanori Akiyama, Fumiaki Watanabe, and Wataru Mizunashi, "Engineering of halohydrin hydrogen-halide-lyase (H-lyase) for efficient L-carnitine production" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/24