In silico approach to better understand the role of active site residue
September 15-19, 2019
Chiral amines are the major building blocks of many life-saving drugs and it has been estimated that nearly 40-45% of the currently used pharmaceuticals contain chiral amine functional groups in their structure. However, the major challenges associated with the chemical synthesis of enantiopure amines are the use of toxic chemicals, formation of many by-products, and multi-step synthesis process. To address these limitations, cost-effective biocatalytic methods are emerging as potential alternatives for the synthesis of chiral amines in enantiomerically pure forms.
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Sindrila Dutta Banik, Shivakumar Venkataraju, Naveen Kulkarni, and Suvamay Jana, "In silico approach to better understand the role of active site residue" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/4