Molecular packaging of biocatalysts using a robust protein cage
September 15-19, 2019
Bacterial microcompartments serve as metabolic modules (pseudo-organelles) that help to increase the local concentration of enzymes, facilitate substrate transfer between a series of connected reactions and sequester potentially toxic substrates or products. Encapsulation of enzyme(s) might be beneficial for biocatalytic approaches due to efficient transfer of intermediates, protection of packaged proteins against proteolysis, extended lifetime of the enzyme and protection against thermal inactivation.
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Nikola Loncar, Henriette J. Rozeboom, Marco W. Fraaije, Linda E. Franken, and Marc C. A. Stuart, "Molecular packaging of biocatalysts using a robust protein cage" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/40