ECI Digital Archives

Title

Molecular packaging of biocatalysts using a robust protein cage

Authors

Nikola Loncar, University of Groningen, NetherlandsFollow
Henriette J. Rozeboom, Molecular Enzymology group, University of Groningen, The Netherlands
Marco W. Fraaije, Molecular Enzymology group, University of Groningen, The Netherlands
Linda E. Franken, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
Marc C. A. Stuart, Department of Electron Microscopy, University of Groningen, The Netherlands

Conference Dates

September 15-19, 2019

Abstract

Bacterial microcompartments serve as metabolic modules (pseudo-organelles) that help to increase the local concentration of enzymes, facilitate substrate transfer between a series of connected reactions and sequester potentially toxic substrates or products. Encapsulation of enzyme(s) might be beneficial for biocatalytic approaches due to efficient transfer of intermediates, protection of packaged proteins against proteolysis, extended lifetime of the enzyme and protection against thermal inactivation.

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Recommended Citation

Nikola Loncar, Henriette J. Rozeboom, Marco W. Fraaije, Linda E. Franken, and Marc C. A. Stuart, "Molecular packaging of biocatalysts using a robust protein cage" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/40