Therapeutic protein expression platform of microbial system
September 15-19, 2019
A number of expression systems have been developed for the production of pharmaceutical products. Pichia pastoris and Escherichia coli expression system operate in our lab and express antibody fragment (scFv), cytokine, protein base adjuvant and vaccine and process enzyme. The expression platform are consisted of three part, first is strain generation , the second is fermentation process development in 250 ml fermentor and the last is process scale-up to 5 litter fermentor.
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Jen-Wei Chang, Ming-Hong Cyue, Chih-Hsi Fan, Neng-Hsien Chang, Wei-Kuang Chi, and Wei-Hong Chen, "Therapeutic protein expression platform of microbial system" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/63