Prenylated Flavin-dependent decarboxylases: Structure-guided engineering and synthetic applicability

Conference Dates

September 15-19, 2019


The recently discovered prenylated flavin (prFMN) cofactor is utilised by UbiD enzyme family to catalyse non-oxidative decarboxylation of precursors of respiratory quinones. Mechanistic aspect of prFMN-mediated decarboxylation has attracted interests and studies of fungal ferulic acid decarboxylases (FDCs), members of the UbiD enzyme family reveal a rare enzymatic 1,3-dipolar cycloaddition mechanism for the decarboxylation of cinnamic aid.

Please click Additional Files below to see the full abstract.

This document is currently not available here.