Prenylated Flavin-dependent decarboxylases: Structure-guided engineering and synthetic applicability
September 15-19, 2019
The recently discovered prenylated flavin (prFMN) cofactor is utilised by UbiD enzyme family to catalyse non-oxidative decarboxylation of precursors of respiratory quinones. Mechanistic aspect of prFMN-mediated decarboxylation has attracted interests and studies of fungal ferulic acid decarboxylases (FDCs), members of the UbiD enzyme family reveal a rare enzymatic 1,3-dipolar cycloaddition mechanism for the decarboxylation of cinnamic aid.
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Godwin Aleku and David Leys, "Prenylated Flavin-dependent decarboxylases: Structure-guided engineering and synthetic applicability" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/76