Cobalamin dependent methylation and demethylation by veratrol O-demethylase
September 15-19, 2019
The formation and breakage of C-O ether bonds are valuable synthetic transformations contributing to the structural diversification of natural products and pharmaceuticals [1-3]. Moreover, O-methylated phenol derivatives are useful building blocks for the manufacture of antioxidants, flavoring agents, fragrances, dyes, agrochemicals and fine chemicals [4,5]. Despite the large variety of chemical reactions for methylation and demethylation, none reaction is reversible and sustainable. They often lack chemo-, regio- and stereoselectivity and rely on harsh reaction conditions . Thus, the development of milder alternatives such as biocatalytic methylation and demethylation reactions is of high interest .
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Christopher Grimm, Simona Pompei, Wolfgang Kroutil, and Judith Farnberger, "Cobalamin dependent methylation and demethylation by veratrol O-demethylase" in "Enzyme Engineering XXV", Huimin Zhao, University of Illinois at Urbana-Champaign, USA John Wong, Pfizer, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/enzyme_xxv/83