Efficient production of soy-bean lecithin – pluronic L64® encapsulated quercetin particles in nanometric scale using sfee and pgss drying processes

Conference Dates

June 19-24, 2016


Quercetin is an antioxidant compound, and it is a highly promising material against a wide variety of diseases, including cancer. A major limitation for the clinical application of quercetin is its low bioavailability, due to its low solubility in water. One way to increase the bioavailability of quercetin is to precipitate it in sub-micrometric scale, encapsulated by a surfactant material, using Supercritical Fluid Extraction of Emulsions (SFEE) and/or Particles from Gas Saturated Solutions (PGSS) drying technology. In this work the efficiency of SFEE- and PGSS drying processes, in producing of quercetin loaded soy-bean lecithin – Pluronic L64® particles in sub-micrometric scale is studied. Robustness study of a batch SFEE process is done, moreover a scaled-up, semi-continuous SFEE process is developed, in order to increase the efficiency of the process, and to decrease the energy consumption. SFEE produced aqueous suspensions are further treated by PGSS drying and by lyophilization, in order to produce solid encapsulated quercetin particles, which are available for long term storage. Encapsulation efficiency and antioxidant activity of with PGSS drying and with lyophilization prepared dried products are measured and compared with each other.

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