Surface modification of magnetite-gold dumbbell nanoparticles with fluorescent dyes for new opportunities in visualization
July 3-7, 2016
Due to unique properties, magnetic nanomaterials are widely used in many branches of science and technology. One of the most perspective and actively developed areas are biomedical application: the target drug delivery, magnetic hyperthermia, biosensors and contrasting materials for magnetic resonance imaging (MRI). Hybrid materials based on nanoparticles with different surface nature as well as different chemical properties represent particularly especial interest. Such materials can be control modified in various ways simultaneously, in particular with drugs and targeted molecules. Surface modification of nanoparticles with fluorescence dyes opens horizons for visualization capabilities, also allows us to trace the behavior of particles in a biological environment, which is essential for their future biomedical applications .
In this work we developed synthetic procedure for of magnetite-gold dumbbell nanoparticles modified with different copolymers containing Fluorescein and modified with Sulfo-Cy5 NHS. Obtained nanoparticles were characterized by variety of methods such as DLS, ICP-MS, and fluorescence microscopy. More detailed information for the synthesis, characterization and biological testing will be discussed in report.
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Alexandra Prelovskaya, Nurgustaana Neustroeva, Natalia Sviridenkova, Alexander Savchenko, and Alexander Majouga, "Surface modification of magnetite-gold dumbbell nanoparticles with fluorescent dyes for new opportunities in visualization" in "Nanotechnology in Medicine: From Molecules to Humans", Prof. Lola Eniola-Adefeso, Department of Chemical Engineering, University of Michigan, USA Prof. Paolo Decuzzi, Italian Institute of Technology, Italy Eds, ECI Symposium Series, (2016). https://dc.engconfintl.org/nanotech_med/35