Adhesion kinetics of functionalized nano-particles under high shear conditions

Conference Dates

June 5-9, 2018


Arterial thrombosis, the formation of blood clot within an artery, is a complex process that consists of multiple steps. These steps are orchestrated by three main factors: high shear flow, prothrombogenic surface (collagen), and blood components mainly von Willebrand factor (vWF) and platelets. One of the essential early events in thrombus initiation under high shear conditions are the interactions between vWF and platelet's receptor GPIbα. Here we study the adhesion kinetics of platelet's GPIbα receptor functionalized-nano particles on different coated-channels under defined hemodynamic conditions.

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