Comparison of alternative single use harvest technologies for large scale harvests of mammalian cell culture processes

Conference Dates

September 23-26, 2018


In a fully disposable facility where the use of continuous disk-stack centrifuges are not preferred, harvest processes based on conventional depth filtration become more challenging with increasing single-use bioreactor (SUB) size and higher density culture. Here, several alternative single-use harvest technologies were evaluated. A disposable centrifuge and a range of different synthetic depth filters were tested. Results showed significant improvement in filterability and reduction of depth filter area compared to full traditional depth filtration train.

49.pdf (5 kB)

This document is currently not available here.