Title

Study of accuracy and selectivity of a hydrogel-based sensor array by Design of Experiments (DOE)

Conference Dates

September 23-26, 2018

Abstract

Reliable continuous sensors are salient to achieving advanced Process Analytical Technologies in the bioproduction industry. Sensors provide information on key parameters in a bioreactor such as physical variables (temperature, pressure, speed of stirrer), chemical variables (pH, pO2, pCO2, nutrients, metabolites), and biological variables (biomass, cell metabolism).1-2 Simultaneously, chemometric analysis using multivariate data analysis, bioprocess modeling, and design of experiments (DOE) have become important in developing advanced biosensors because of the need to clean the complex raw data from biosensors to provide repeatable, robust, and reliable information.3-4 In this work, the first step of the chemometric analysis process, DOE was performed with a prototype biosensor developed to simultaneously monitor glucose, lactate, pH, and osmolarity to understand the accuracy and selectivity of this sensor.

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