Flexible organic thin film transistors for high-performance biosensors
May 19-23, 2019
Solution-gated transistors have shown promising applications in biosensors due to the high sensitivity, low working voltage and the simple design of the devices. Solution-gated transistors normal have no gate dielectric and the gate voltages are applied directly on the solid/electrolyte interfaces or electric double layers near the channel and the gate, which lead to very low working voltages (about 1 V) of the transistors. On the other hand, the devices can be easily prepared by solution process or other convenient methods because of the much simpler device structure compared with that of a conventional field effect transistor with several layers. Many biosensors can be developed based on the detection of potential changes across solid/electrolyte interfaces induced by electrochemical reactions or interactions. The devices normally can show high sensitivity due to the inherent amplification function of the transistors. In this talk, I will introduce several types of biosensors studied by our group recently, including DNA, glucose, dopamine, uric acid, cell, protein  and bacteria sensors, based on flexible solution-gated organic thin film transistors. The biosensors show high sensitivity and selectivity when the devices are modified with functional nano-materials (e.g. graphene, Pt nanoparticles) and biomaterials (e.g. enzyme, antibody, DNA) on the gate electrodes or the channel. Furthermore, the devices are miniaturized successfully for the applications as sensing arrays . The solution-gated organic devices are also used for voltage-controlled drug release in aqueous solutions . It is expected that the solution-gated organic transistors will find more important applications especially wearable electronics for healthcare in the future [8,9].
 Lin P., Yan F., et al. Adv. Mater. 23, (2011) 4035-4040.
 Tang H., Yan, F. et al. Adv. Funct. Mater. 21, (2011) 2264-2272.
 Liao C. Z., Yan F., et al. Adv. Mater. 27, (2015) 676-681.
 Lin P., Yan F., et al. Adv. Mater, 22, (2010) 3655-3660.
 Fu Y., Yan F., et al. Adv. Mater. (2017) DOI: 10.1002/adma. 201703787.
 Liao C. Z., Yan F., et al. Adv. Mater. 27, (2015) 7493-7527.
 Liu S. H., Yan F. et al Adv. Mater. 29, (2017) 1701733.
 Yang A. N., Yan F. et al. dv. Mater. 30, (2018) 1800051.
 Wang N. X., Yang A. N., Fu Y., Li Y. Z., and Yan F., Acc. Chem. Res. (2019).
Feng Yan, "Flexible organic thin film transistors for high-performance biosensors" in "Semiconductor Technology for Ultra Large Scale Integrated Circuits and Thin Film Transistors VII", Yue Kuo, Texas A&M University, USA Junichi Murota, Tohoku University, Japan Yukiharu Uraoka, Nara Advanced Institute of Science and Technology, Japan Yasuhiro Fukunaka, Kyoto University, Japan Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/ulsic_tft_vii/40