June 12 – 17, 2022
Product quality understanding is a critical part of viral vector vaccine manufacturing and regulation. Mass spectrometry is a technique that has widely been applied to protein-based therapeutics and could be used as a characterisation tool to monitor viral vector vaccine product quality. The ultimate objective of this Bill and Melinda Gates Foundation funded project is to enable vaccine manufacturing in Low and Middle-income countries (LMIC) through increased scientific understanding of viral vector vaccine manufacturing bottlenecks and therefore de-risking of vaccine development and manufacturing.
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Shaleem I. Jacob, John M. Hickey, Andrew Tait, Fatemeh Dastjerdi Vahid, Sarah Rouse, Joseph Barritt, Alexander Douglas, Sangeeta B. Joshi, David B. Volkin, and Daniel G. Bracewell, "Development of analytical characterization tools for process monitoring of adenovirus-based vaccines (ChAdOx and Ad5)" in "Vaccine Technology VIII", Tarit Mukhopadhyay, Merck Research Laboratories, USA; Charles Lutsch, Sanofi Pasteur, France; Linda Hwee-Lin Lua, University of Queensland, Australia; Francesc Godia, Universitat Autònoma de Barcelona, Spain Eds, ECI Symposium Series, (2022). https://dc.engconfintl.org/vaccine_viii/28