Continuous purification of cell culture-derived influenza A virus particles through pseudo- affinity membrane chromatography

Conference Dates

June 17-22, 2018


Continuous manufacturing is a relevant trend in biopharmaceutical production to reduce the process footprint and to improve the process economy. Vaccines against world-spread diseases, such as influenza, should benefit in particular from such an approach, given the increasing demand for seasonal vaccines and the need for a fast response in case of a pandemic outbreak. Upstream processing of viral vaccines has seen important progress in continuous production of viral vaccines [1], which further supports the development of hybrid or fully continuous flow-schemes for downstream processing.

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