Feeding TCA Cycle Intermediates for pH control improves CHO cell culture performance and increases TCA cycle flux

Authors

• Sandra Bennum, Merck & Co., Inc., USAFollow
• Kevin J. Ruiz-Marquez, Department of Chemical and Biomolecular Engineering, Vanderbilt University, USA
• Irina Trenary, Department of Chemical and Biomolecular Engineering, Vanderbilt University, USA
• Rachel Moen, Department of Chemical and Biomolecular Engineering, Vanderbilt University, USA
• Xiaolin Zhang, Biologics Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA
• Henry Lin, Biologics Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA
• Malik Padellan, Biologics Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA
• Xiaowen Wang, Biologics Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA
• Jamey D . Young, Department of Chemical and Biomolecular Engineering, Vanderbilt University, USA

Conference Dates

April 27 - May 2, 2025

Abstract

Please click Additional Files below to see the full abstract

Recommended Citation

Sandra Bennum, Kevin J. Ruiz-Marquez, Irina Trenary, Rachel Moen, Xiaolin Zhang, Henry Lin, Malik Padellan, Xiaowen Wang, and Jamey D . Young, "Feeding TCA Cycle Intermediates for pH control improves CHO cell culture performance and increases TCA cycle flux" in "Cell Culture Engineering XIX", A Khetan, BMS; Marcella Yu, Gilead; Mike Betenbaugh, Johns Hopkins University Eds, ECI Symposium Series, (2025). https://dc.engconfintl.org/cell_culture_engineering_xix/126