Leveraging a RNA-based lipid nanoparticle (LNP) gene writer system to generate Chimeric Antigen Receptor T cells (CAR-T) for in vitro and in vivo tumor activity

Authors

Jason Rodriguez, Tessera Therapeutics, USA
Pooja Sabhachandani, PhD, Tessera Therapeutics, Inc., Somerville, MA 02143, USAFollow
Kevin Johnson, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Oscar Cabrera, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Chris J. Caleca, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Michael S. Magee, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Alberto De Iaco, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Kassi T. Stein, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
James B. Rottman, PhD, DVM, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Donghui Li, PhD, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Mohit Gupta, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Michael T. Monte, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Jane Wang, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Bill Querbes, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Michael C . Holmes, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Cecilia Cotta-Ramusino, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Madhusudan V. Peshwa, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Yu Cao, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Rebecca Levy, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
Giulia Schiroli, Tessera Therapeutics, Inc., Somerville, MA 02143, USA

Conference Dates

February 4 - 8, 2024

Abstract

Please click Additional Files below to see the full abstract.

Recommended Citation

Jason Rodriguez; Pooja Sabhachandani; Kevin Johnson; Oscar Cabrera; Chris J. Caleca; Michael S. Magee; Alberto De Iaco; Kassi T. Stein; James B. Rottman, PhD; Donghui Li, PhD; Mohit Gupta; Michael T. Monte; Jane Wang; Bill Querbes; Michael C . Holmes; Cecilia Cotta-Ramusino; Madhusudan V. Peshwa; Yu Cao; Rebecca Levy; and Giulia Schiroli, "Leveraging a RNA-based lipid nanoparticle (LNP) gene writer system to generate Chimeric Antigen Receptor T cells (CAR-T) for in vitro and in vivo tumor activity" in "Advancing Manufacture of Cell and Gene Therapies VIII", Fernanda Masri, Cytomos, United Kingdom; Carolyn Yeago, CY Solutions LLC, USA; Gargi Maheshwari, BMS, USA; John Moscariello, BMS, USA Eds, ECI Symposium Series, (2024). https://dc.engconfintl.org/cell_gene_therapies_viii/96