Leveraging a RNA-based lipid nanoparticle (LNP) gene writer system to generate Chimeric Antigen Receptor T cells (CAR-T) for in vitro and in vivo tumor activity

Authors

• Jason Rodriguez, Tessera Therapeutics, USA
• Pooja Sabhachandani, PhD, Tessera Therapeutics, Inc., Somerville, MA 02143, USAFollow
• Kevin Johnson, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Oscar Cabrera, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Chris J. Caleca, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Michael S. Magee, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Alberto De Iaco, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Kassi T. Stein, BS, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• James B. Rottman, PhD, DVM, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Donghui Li, PhD, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Mohit Gupta, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Michael T. Monte, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Jane Wang, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Bill Querbes, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Michael C . Holmes, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Cecilia Cotta-Ramusino, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Madhusudan V. Peshwa, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Yu Cao, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Rebecca Levy, Tessera Therapeutics, Inc., Somerville, MA 02143, USA
• Giulia Schiroli, Tessera Therapeutics, Inc., Somerville, MA 02143, USA

Conference Dates

February 4 - 8, 2024

Abstract

Please click Additional Files below to see the full abstract.

Recommended Citation

Jason Rodriguez; Pooja Sabhachandani; Kevin Johnson; Oscar Cabrera; Chris J. Caleca; Michael S. Magee; Alberto De Iaco; Kassi T. Stein; James B. Rottman, PhD; Donghui Li, PhD; Mohit Gupta; Michael T. Monte; Jane Wang; Bill Querbes; Michael C . Holmes; Cecilia Cotta-Ramusino; Madhusudan V. Peshwa; Yu Cao; Rebecca Levy; and Giulia Schiroli, "Leveraging a RNA-based lipid nanoparticle (LNP) gene writer system to generate Chimeric Antigen Receptor T cells (CAR-T) for in vitro and in vivo tumor activity" in "Advancing Manufacture of Cell and Gene Therapies VIII", Fernanda Masri, Cytomos, United Kingdom; Carolyn Yeago, CY Solutions LLC, USA; Gargi Maheshwari, BMS, USA; John Moscariello, BMS, USA Eds, ECI Symposium Series, (2024). https://dc.engconfintl.org/cell_gene_therapies_viii/96