ECI Digital Archives

Title

Anthracyclines gels: Chemical structure and functional behaviour

Authors

Mauro Giustini, Chemistry Department, University “La Sapienza”, 00185 Rome, Italy CSGI (O.U. of Bari), Chemistry Department, University of Bari, 70126 Bari, ItalyFollow
Anna Maria Giuliani, STEBICEF Department, University of Palermo, Italy
Luciano Galantini, University “La Sapienza”, Italy
Marco D’Abramo, University “La Sapienza”, Italy
Oriona Dhamo, University “La Sapienza”, Italy
Gerardo Palazzo, Chemistry Department and CSGI, University of Bari, Italy

Conference Dates

July 10-14, 2016

Abstract

Anthracyclines are a family of antibiotics often used in cancer chemotherapy. Daunorubicin (DA) was the first isolated from a strain of Streptomyces peucetius back in 1960 and still in use for the treatment of several malignancies together with the even more frequently used analogue Doxorubicin (DX, also called Adriamycin) and its semisynthetic derivative Epirubicyn (EPI). Despite their extremely close chemical formula (Figure 1), their properties when in solution are enormously different. In fact, whereas the increase of the ionic strength induces the formation of a gel with DX^1-3, in the case of the related EPI and DA molecules what is observed are only the well-known self-association phenomena documented in the literature from decades⁴.

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Recommended Citation

Mauro Giustini, Anna Maria Giuliani, Luciano Galantini, Marco D’Abramo, Oriona Dhamo, and Gerardo Palazzo, "Anthracyclines gels: Chemical structure and functional behaviour" in "Colloidal, Macromolecular & Biological Gels: Formulation, Properties & Applications", ECI Symposium Series, (2016). https://dc.engconfintl.org/cmb_gels/40