Title
In-vivo evaluation of biocompatibility of biodegradable Fe-Mn materials
Conference Dates
November 12-16, 2017
Abstract
The authors evaluated the biodegradability and biocompatibility of an alloy of iron and manganese in a bone model in vivo. Fe-Mn biodegradable materials with various porosities were first fabricated and characterized for microstructure, corrosion and mechanical properties.
Resorption of a bioabsorbable wire of chemical formula Fe30Mn and no induced porosity was evaluated in-vivo. The Fe-Mn alloy behavior in-vivo was compared to that of a traditional permanent 316L stainless steel (SS) wire after bilateral transcondylar femoral implantation in 12 rats. Evaluation of biodegradation was performed over a period of 6 months using serial radiography, post-mortem histology and macroscopic implant surface analysis. Increased bone ingrowth was noted at the iron-manganese wire-bone interface, which indicates increased osseointegration of the implant.
Please click Additional Files below to see the full abstract.
Recommended Citation
Sabrina Huang, Marine Traverson, Michael Heiden, Lia A. Stanciu, Eric A. Nauman, Gert J. Breur, and Yava Jones-Hall, "In-vivo evaluation of biocompatibility of biodegradable Fe-Mn materials" in "Composites at Lake Louise 2017", Eric Duoss, Lawrence Livermore National Laboratory, USA Waltraud M. Kriven, University of Illinois at Urbana-Champaign, USA Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/composites_all_2017/18