In-vivo evaluation of biocompatibility of biodegradable Fe-Mn materials

Conference Dates

November 12-16, 2017


The authors evaluated the biodegradability and biocompatibility of an alloy of iron and manganese in a bone model in vivo. Fe-Mn biodegradable materials with various porosities were first fabricated and characterized for microstructure, corrosion and mechanical properties.

Resorption of a bioabsorbable wire of chemical formula Fe30Mn and no induced porosity was evaluated in-vivo. The Fe-Mn alloy behavior in-vivo was compared to that of a traditional permanent 316L stainless steel (SS) wire after bilateral transcondylar femoral implantation in 12 rats. Evaluation of biodegradation was performed over a period of 6 months using serial radiography, post-mortem histology and macroscopic implant surface analysis. Increased bone ingrowth was noted at the iron-manganese wire-bone interface, which indicates increased osseointegration of the implant.

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