Title
Development of biocompatible small-molecule spacers as metal oxide nanoparticles' stabilizing agents
Conference Dates
July 3-7, 2016
Abstract
Development and study of the magnetic nanoparticles for biological and clinical applications remains one of the challenging research areas in chemistry and materials science. The performance of these particles as, for example, drug delivery, MRI, hyperthermia or cell tracking agents, depends on their magnetic susceptibility. Their ability to form stable aqueous colloids, the mobility, and diffusion properties in biological media, rely on organic coating, which is usually composed of hydrophilic biocompatible polymers such as dextrans or poly(ethylene glycol)s. Some areas of biomedical imaging, labeling and delivery application can benefit from magnetic nanoparticles with higher mobility and penetration, stronger interaction with fluids and tissues, and that can be easily conjugated to biological molecules. The idea of this work was to develop a non-polymeric organic coating of an adjustable size, which might offer a simpler way to obtaining particles with these properties.
Our target capping ligands were based on aromatic polycarboxylic acids that would strongly bind to the nanoparticle’s surface, and assure the adduct’s stability in aqueous colloids. The precursor acids were functionalized with oligomeric ethylene oxide and glycerol derivatives and covalently bound to the surface of 5 nm γ-Fe2O3 nanoparticles in reaction with their surfactant-free diethylene glycol colloids. Results of colloidal studies on these adducts will be presented.
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Recommended Citation
Galina Goloverda, Huy Do, Ezinne U. Agwaramgbo, Anastasia LaBeaud, Rajesh Komati, and Vladimir Kolesnichenko, "Development of biocompatible small-molecule spacers as metal oxide nanoparticles' stabilizing agents" in "Nanotechnology in Medicine: From Molecules to Humans", Prof. Lola Eniola-Adefeso, Department of Chemical Engineering, University of Michigan, USA Prof. Paolo Decuzzi, Italian Institute of Technology, Italy Eds, ECI Symposium Series, (2016). https://dc.engconfintl.org/nanotech_med/32