Sustained release vaccine platforms for enhanced humoral immunity
June 5-9, 2018
Vaccines aim to modulate the immune system to elicit a sufficiently robust, yet targeted, immune response with specifiable immune cell phenotypes.1,2 Failure of a single vaccine administration to elicit such a response likely arises from inappropriate temporal control over antigen/adjuvant presentation and immune cell activation.2 Recent work demonstrates the potential for sustained, low-level presentation of antigens and adjuvants for just over a week to yield more potent and long-lasting immunity.3
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Gillie Agmon, Emily Gale, Caitlin Maikawa, Anthony Yu, and Eric Appel, "Sustained release vaccine platforms for enhanced humoral immunity" in "Nanotechnology in Medicine II: Bridging Translational in vitro and in vivo Interfaces", Millicent Sullivan, PhD, University of Delaware, USA Josué Sznitman, Dr. Sc., Technion-Israel Institute of Technology, Israel Lola Eniola-Adefeso, PhD, University of Michigan, USA Srivatsan Kidambi, PhD, University of Nebraska - Lincoln, USA Eds, ECI Symposium Series, (2018). https://dc.engconfintl.org/nanotech_med_ii/1