Conference Dates
June 12 – 17, 2022
Abstract
The recent pandemic emphasises the need for vaccine producers to be able to respond rapidly to the need for large quantities for global distribution. Here, we report work to optimise a perfusion-based upstream approach. Perfusion can enhance volumetric productivity of adenoviral vectors, but the complexity of perfusion culture and the lack of suitable scale-down models has hindered work to establish the complex relationships between variables affecting the process.
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Recommended Citation
Carina C.D. Joe, Steffi Scholze, Julia Niemann, and Alexander D. Douglas, "Use of a parallel bioreactor scaledown system for optimisation of a perfusion-based upstream process for adenovirus production" in "Vaccine Technology VIII", Tarit Mukhopadhyay, Merck Research Laboratories, USA; Charles Lutsch, Sanofi Pasteur, France; Linda Hwee-Lin Lua, University of Queensland, Australia; Francesc Godia, Universitat Autònoma de Barcelona, Spain Eds, ECI Symposium Series, (2022). https://dc.engconfintl.org/vaccine_viii/117