June 12 – 17, 2022
Sitges, Spain
| Chairs: | Tarit Mukhopadhyay, Merck Research Laboratories, USA |
|---|---|
| Charles Lutsch, Sanofi Pasteur, France | |
| Linda Hwee-Lin Lua, University of Queensland, Australia | |
| Francesc Godia, Universitat Autònoma de Barcelona, Spain |
The articles for these proceedings are not peer-reviewed.
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Evaluation of a low-serum medium for growth and virus production with MRC-5 cells cultured on Cytodex 1 microcarriers, Michael Bruno, Haaris Huzair, and Anna-Barbara Hachmann (Abstract)
Development of two monovalent antivenoms against two Moroccan viper venoms– daboia Mauritanica and Cerastes Cerastes, Naoual Oukkache, José Marcelino, and Abderrahmane Maaroufi (Abstract)
Development of the filamentous fungus Thermothelomyces heterothallica C1 into a next-generation production platform for human and animal vaccines, Ronen Tchelet, Marika Vitikainen, Noelia Valbuena, Anne Huuskonen, Abraham Nyska, Markku Saloheimo, and Mark Emalfarb (Abstract)
An adenovirus-based vaccine manufacturing technology platform for mucosal or parenteral immunization against poultry diseases in sub-Saharan Africa, Omar Farnós, Esayas Gelaye, Samia Rourou, Alya Soudani, Khaled Trabelsi, Alice Bernier, Kumar Subramaniam, Martha Yami, and Amine A. Kamen (Abstract)
Production and purification of an immunogenic G protein of rabies virus from S2 insect cells, Renato Mancini Astray, Livia Pillati, Mayra Pereira Rocca, Flavia Ferreira Barbosa, Helio Langoni, Benedito Menozzi, Soraia Attie Calil Jorge, and Elisabeth Augusto (Abstract)
Enhancing production of the malaria asexual blood-stage vaccine candidate PfRipr5 in insect cells by modulating expression vector and culture temperature, Ricardo Correia, Eizo Takashima, Takafumi Tsuboi, Akihisa Fukushima, Sophie Houard, Manuel Carrondo, and António Roldão (Abstract)
Acceleration of vaccine development by improvement of process understanding - Analysis of the host cell proteome, Roxana Disela, Daphne Keulen, Geoffroy Geldhof, Olivier Le Bussy, Martin Pabst, and Marcel Ottens (Abstract)
Microbial platform for vaccine production for Low-and Medium-Income Countries (LMICs): 2 case studies, Salomé de Sá Magalhães, Stephen A. Morris, M. Lourdes Velez-Suberbie, Acep Riza Wijayadikusumah, Neni Nurainy, and Eli Keshavarz-Moore (Abstract)
Optimization of rAd5 vectored Newcastle vaccine production in HEK293 at high cell densities, Samia Rourou, Amani Chaaben, Alya Soudani, Meriem Ben Zakour, Omar Farnós, Esayas Gelaye, Martha Yami, Amine Kamen, Khaled Trabelsi, and Héla Kallel (Abstract)
Towards a virus production platform based on VeroS cells grown on chemically defined media, Samia Rourou and Ikram Ben Marzouk (Abstract)
Influenza A virus-derived defective interfering particles for antiviral treatment, Sascha Y. Kupke, M D. Hein, Y Genzel, L Pelz, P Marichal-Gallardo, N Bdeir, S Pöhlmann, U Rand, L Cicin-Sain, F Alnaji, C Brooke, M Winkler, L Cicin-Sain, D Bruder, K Schughart, and U Reichl (Abstract)
Virus like particles expressed in insect cells and mammalian cells as a plataform for the development of a Zika vaccine, Selene J. Uribe, Ana Ruth Pastor, Diego Fontana, Claudio Prieto, Octavio T. Ramírez, and Laura A. Palomares (Abstract)
Mutation of a conserved, hydrophobic, cryptic epitope improves manufacturability and immunogenicity of the SARS-CoV-2 RBD, Sergio Rodriguez Aponte, Neil C. Dalvie, Ting Y. Wong, F. Heath Damron, and J. Christopher Love (Abstract)
A quality- by- design approach for the implementation of a manufacturing license change using a qualified scale- down process model, Shari Narayanan,; Kulwinder Banger; Jasmine Fearnley; and Andrea CME Rayat (Abstract)
Intranasal administration of NDV-HXP-S COVID19 vaccines induces robust protective mucosal and systemic immunity in mice, Stefan Slamanig, Weina Sun, Irene Gonzalez, Nicholas Lemus, and Peter Palese (Abstract)
Adapting Flublok/supemtek® recombinant protein expression systems to Sars-cov-2, Steven Hauser, Val Mermall, Nikolai Khramtsov, and Ronald Neeleman (Abstract)
Production of a fusogenic oncolytic rVSV-NDV virus in perfusion processes, Sven Göbel, Marie Dorn, Karim Jaén Chavez, Ingo Jordan, Volker Sandig, Jennifer Altomente, Yvonne Genzel, and Udo Reichl (Abstract)
Upstream process optimization to support efficient HEK293 cell growth and adenovirus production, Syed Muaz Khalil, Wen-Yang Tsai, and Anna-Barbara Hachmann (Abstract)
Lessons in vaccine process development, Tara Tagmyer (Article)
Development of a standardized multiplex Filovirus and SARS-CoV2 antibody immunoassay, Teri Ann S. Wong, Albert To, and Axel Lehrer (Abstract)
Biophysical technologies in vaccines, Hervé Ponceblanc, Marco Garrido Sergio, and Stephanie Prizzon (Abstract)
Automated single-cell cloning in chemically defined medium for new suspension MDCK cell lines and scale-down of influenza A virus production into ambr®15 microbioreactors, Tilia Zinnecker, Ilona Behrendt, Maverick Lau, Angelika Hinkelmann, Kristin Thiele, Najd Badri, Diogo Araujo, Yvonne Genzel, and Udo Reichl (Abstract)
Producing viruses in orbit: Current developments for orbital shaken viral vaccine manufacturing, Tim Bürgin, Juliana Coronel, Katharina Fiddeke, Volker Sandig, Yvonne Genzel, Udo Reichl, and Tibor Anderlei (Abstract)
Multimodal chromatography combining steric exclusion and cation exchange as an intermediate downstream step to purify yellow fever virus-like particles, Túlio M. Lima, Ricardo A. Medronho, and Leda R. Castilho (Abstract)
Towards updatable, multivalent Covid vaccines: A platform process to produce trimeric spike protein of SARS-COV-2 variants expressed in HEK293 stable cell clones, Renata G.F. Alvim, Tulio M. Lima, Federico F. Marsili, and Leda R. Castilho (Abstract)
Salt tolerant endonucleases for the removal of host cell DNA in Downstream Processing of enveloped viruses, Viktoria Mayer, Patricia Pereira Aguilar, and Alois Jungbauer (Abstract)
Pre-fabrication for providing biocapacity to support vaccine manufacturing, Martin Birch and Thomas Hauser (Abstract)
A platform approach for the production of Hand, Foot, Mouth Disease vaccines, Yvonne Thomassen, Emilie Rodrigues, Aart van ’t Oever, Wouter van den Braak, and Dinja Oosterhoff (Abstract)
Genetically detoxified diphtheria and tetanus toxins, EcoCRM197® and 8MTT, expressed in an engineered E. coli strain and use as conjugate vaccine carrier proteins, Andrew Lees, Morgane Ollivault-Shiflett, Min-Ju Chang, and Renaud Jacquemart (Abstract)
Affinity purification of SARS-COV-2 spike protein receptor binding domain produced in a C1 fungal expression system, Amit Dutta, Aditya Utturkar, Ronen Tchelet, Noelia Valbuena Crespo, Laura Mueller, and Renaud Jacquemart (Abstract)
Workshop: Process intensification considerations for LMIC, Philippe Alexandre Gilbert (Abstract and Presentation)