October 5-9, 2025
Dubrovnik, Croatia
| Chairs: | Irina Ramos, AstraZeneca |
|---|---|
| Mark Brower, Merck | |
| Alois Jungbauer, BOKU | |
| K. Brower, Sanofi |
25 conference program - Integrated Continuous Biomanufacturing VII, Kevin Brower, Alois Jungbauer, Mark Brower, and Irina Ramos (Article)
Reinforcement learning for automated control of semi-continuous chromatography, Foteini Michalopoulou, Maria M. Papathanasiou, and Emmanouil Papadakis (Abstract)
Building a digital integrated continuous purification platform – approaches for next gen process development and contro, Sushmitha Krishnan, Peter Firmin, Kevin Brower, Michael Coolbaugh, Jason Walther, Thomas Wasylenko, Ricardo Suarez Heredia, Gabriele Bano, Anastasia Nikolakopoulou, and Thomas Liao (Abstract)
CPI’s end-to-end continuous Intensified Biomanufacturing Platform: accelerating innovation in bioprocess development and sustainability, Liam Nattrass, Joseph Zeguer, and Kevin Kokkad (Abstract and Presentation)
Simultaneous scheduling and control of Protein A chromatography for integration to dynamic upstream conditions, Ian Gough, Brandon Corbett, David R. Latulippe, Christopher L.E. Swartz, and Prashant Mhaskar (Abstract)
Role of AI -ML in next generation biopharmaceutical manufacturing, Anurag Rathore (Abstract)
From batches to flow: Transforming downstream processing into a continuous enterprise, Alois Jungbauer (Abstract and Presentation)
Continuous manufacturing of vaccines, for rapid response to the next Disease X, Renske Hesselink (Abstract)
Empowering 5.0 biosolutions through continuous realtime PAT and computational controls reducing waste, while saving time and cost, Edita Botonjic-Sehic (Abstract)
Enabling continuous biomanufacturing for virus-based expression systems via multi-stage bioreactors, António Roldão, Taja Zotler, Ricardo l Correia, Taja Zotler, Birhanu Hurisa, Gorben Pijlman, and Paula M. Alves (Abstract)
High performance countercurrent membrane purification for continuous processing of RNA therapeutics 1, Andrew Zydney and Ziqiao Wang (Abstract and Presentation)
Integrated continuous downstream process for non-enveloped virus-like particles, Lukas Gerstweiler, Jingxiu Bi, and Anton Middelberg (Abstract and Presentation)
Industrial Symbiosis: How local cross-sectoral collaborations can help transform industrial production towards a circular economy – surplus from circular production, Per Møller (Abstract)
Enhancing filtration performance in perfusion cell culture across scales, Patrick Romann, Antony Sibilia, Jannis Bähler, Philip Giller, and Thomas K. Villiger (Abstract)
In-line secondary clarification of perfusate: Evaluation of tangential flow and depth filtration, Lauriane Gaudette, Allyson Caron, Timothy Hwang, and Jessica Zuponcic (Abstract)
Machine learning-driven cell line selection for high-density perfusion culture, Shuhei Katayama, Maiko Wakita, Keiichi Onodera, Ken Matsui, Tatsuya Matsuura, Yuanzhong Li, Yuta Murakami, John Raven, Leon Pybus, and Shinichi Nakai (Abstract)
Harmonized media platform and clone selection framework combined with a strategy to modulate cell growth for developing highly productive continuous bioprocess, Venkata Tayi, Erin Kotzbauer, Kyle Devenney, Suyang Wu, and Karen Lee (Abstract)
Recycling perfusion platform for continuous mAb production using SPTFF permeate, Jaeweon Lee, Seong-Yeon Song, Hiroaki Yamanaka, and Aravindan Rajendran (Abstract and Presentation)
Integrating PAT: Automated sampling, on-line analysis and real-time control of perfusion cell culture processes, James Angelo, Gujie Mi, Jean-Luc Gerling, and Matthew Wong (Abstract and Presentation)
Towards continuous bioprocessing: A Mid-infrared spectroscopy PAT for real-time monitoring, Alexander Geissler, Camilla Marasca, Ariana Peredo, and Niklas Zell (Abstract)
Control of column switch time for continuous antibody capture based on mAb flowthrough concentration using in-line novel PAT, Maja Sondell, Niklas A ndersson, and Bernt Nilsson (Abstract and Presentation)
Mechanistic modeling of retention time distribution for continuous Protein A affinity capture, Wu-Wei Chen, Liang-Zhi Qiao, Yan-Na Sun, Alois Jungbauer, Shan-Jing Yao, and Dong-Qiang Lin (Abstract)
Overcoming the challenges of freeze-drying biological drugs in unit-dose formats: Transitioning from batch to continuous processing, Robert Pisano, Steven J. Burcat, Bernhardt L. Trout, Alexander H. Slocum, Richard D. Braatz, Rohan P. Kadambi, and Lorenzo Stratta (Abstract)
Breaking barriers in biomanufacturing: A novel end-to-end continuous processing line, Martin Lobedann and Thomas Kruse (Abstract and Presentation)
Bulk crystallization for protein processing: New concepts, challenges and opportunities, Dorota Antos, Michał Kołodziej, Bartłomiej Filip, and Wojciech Piątkowski (Abstract)
Sustainable, precipitation-based continuous downstream processing for mAbs, Todd Przybycien, Matthew R. Mergy, Mario A. Gutierrez-Diaz, Yuncan Zhu, Steven M. Cramer, and Andrew L. Zydney (Abstract)
Implementation of viral filtration in a continuous end to end process, Megan McClure, Eva Gefroh, and Jodi Chie (Abstract)
A 30 kg/day one-step process for continuous concentration, buffer exchange, and formulation of biologics, Ujwal Patil, Michelle Chen, Irina Ramos, and Jon Coffman (Abstract)
Mitigating cell retention filter fouling for 2000L high-density perfusion culture, Naomichi Hikichi, Kosuke Taniguchi, Shunichi Yoshida, Shinichi Nakai, John Raven, and Leon Pybus (Abstract)
From lab to GMP: The manufacturing implementation of an integrated concept, Benoit Mothes, Celia Valentim, Kevin Brower, and Marc Ferron (Abstract)
Enabling high-productivity integrated continuous biomanufacturing through distributed control systems, Mingyue Fang, Hang Zhou, and Weichang Zhou (Abstract)
Manufacturing-scale integrated continuous biomanufacturing: Implementation insights and lessons learned, Kevin Ingham, Eva Gefroh, and Megan McClure (Abstract)
Overcoming challenges with scale-up and GMP implementation of an integrated dynamic bioprocessing (IDB) platform for multiple products, Nicole Bleckwenn (Abstract)
Advancing Integrated Continuous Bioprocessing to Transform Biologics Manufacturing, Weichang Zhou (Abstract)
Innovative single-use system for preparation of concentrated stock solutions – A critical enabling technology developed for intensifying biomanufacturing processes, Mike Su (Abstract)
Intensification of oncolytic Newcastle disease virus production, Lennart Jacobtorweihe, Brice Madeline, Arnaud Léon, Yvonne Genzel, and Udo Reichl (Abstract and Presentation)
Rational approach to reducing the viral contamination risk in integrated continuous biomanufacturing, Takao Ito (Abstract)
Continuous purification from development to commercial scales, Joanna Pezzini (Abstract and Presentation)
Continuos downstream process orchestration in Pionic platform, Alexandre Espachs Barroso, Jérôme Chevalier, Niclas Storck, and Cyril. Mak (Abstract)
Optimization of cell expansion phase parameters for a cost-effective lentiviral vector perfusion process, Marta Arrizabalaga Cascallana, Parameswari Singh, Holger Laux, Stephen Goldrick, and Qasim A. Rafiq (Abstract)
An integrated perfusion process for cell culture-based production of an oncolytic VSV virus, Sven Göbel, Rita Fernandes, Lennart Jacobtorweihe, Christina Peixoto, Jennifer Altomonte, Udo Reichl, and Yvonne Genzel (Abstract)
Does continuous processing have to be single use?, Mark Schofield, Kurt Boenning, Ruth de la Fuente Sanz, and Christina Caporale (Abstract)
An intensified single-step, flowthrough polishing process: A closer look at aggregate and mock virus removal with Capto adhere, Kurt Boenning, Christina Caporale, Mark Schofield, Julio Huato Hernandez, and Elizabeth Olsson (Abstract)
Extraction of recombinant proteins from E. coli fermentation broths by polyethyleneimmine as efficient tool for process intensification, Rainer Hahn, Alexander Jurjevec, Cécile Brocard, Monika Cserjan, and Gerald Striedner (Abstract)
Towards Integrated Continuous Biomanufacturing of Aav, Thomas K. Villiger, Julia Müller, Richard Plieninger, Sven Göbel, Yuki Higuchi, Ryosuke Takahashi, Sebastian Vogg, and Thomas Müller-Späth (Abstract)
Fully integrated and continuous precipitation-based process for the purification of mRNA, Maria del Carme Pons Royo, Rajan R. Bhawnani, Richard D. Braatz, and Allan S. Myerson (Abstract)
Approaches to virus filtration validation in continuous bioprocessing, Julie Kozaili and Daniel Strauss (Abstract)
Continuous operation enables cold ethanol precipitation of intravenous immunoglobulin G within one minute, Nico Lingg, Markus Mozgovicz, Alois Jungbauer, and Theresa Schaufler (Abstract)
The journey towards a continuous rAAV production, Richard Plieninger, Francesco Iannacci, Julia Müller, Thomas K. Villiger, and Sven Göbel (Abstract)
Paving technological gaps to transition into continuous bioprocessing of hPSC, Daniel Komuczki, Léa Ledaine, Monica Jara-Avaca, Allan Ertmann Karlsen, Dorthe Rønn-Petersen, Mattias Hansson, and Manuel Quirós (Abstract)
Improving AAV8 purification with continuous affinity capture: From batch to continuous multicolumn chromatography, Ricardo Silva, Salomé Neto, Greig Rankine, and Franziska Bollmann (Abstract)
From 500L to 2000L high cell density perfusion culture: Optimizing O2 delivery, John Raven, Takashi Kurosawa, Shunichi Yoshida, Kosuke Taniguchi, Shuhei Katayama, Shinichi Nakai, and Leon Pybus (Abstract)
Towards seamless Mab purification: Dual step Mcc on the octave platform, Carsten-René Arlt, Sebastian Thürmann, and Jonas Wege (Abstract)
A combination of machine learning and CFD simulations to enable control and scaling of continuous bioprocesses, Christian Witz, Lukas Gsenger, Michael Wagner, Philipp Eibl, and Johannes Khinast (Abstract and Presentation)
Continuous alkaline lysis of plasmid-containing E. coli cells using an oscillatory flow reactor, A. Rita Silva-Santos, Carla l Lopes, Diogo Ferreira-Faria, and Ana M. Azevedo (Abstract)
No two runs alike: Cycle-to-cycle variation in recovery during virus membrane chromatography, Claire Velikonja, Brandon Corbett, Chris McCready, Prashant Mhaskar, and David Latulippe (Abstract)
Development of a small-scale continuous virus filtration model incorporating inline spiking and mixing, Ioana Pintescu, Julie Kozaili, and Daniel Strauss (Abstract)
Integrated purification of recombinant protein A from secreting E. coli – enabling simplified microbial bioprocessing through magnetic bare iron oxide nanoparticles, Julian Galbusera, Friederike Eilts, and Sonja Berensmeier (Abstract and Presentation)
Challenges experienced in steady state perfusion and development of a new dynamic perfusion platform, Charles Budde, William Napoli, Adam Osborne, Henry Lin, and Lydia Waldek (Abstract)
Model-assisted process development of continuous chromatography for mRNA affinity capture, Liang-Zhi Qiao, Wu-Wei Chen, Dong-Qiang Lin, and Shan-Jing Yao (Abstract)
Q-learning agent-based level control of surge tanks for improved continuous manufacturing of monoclonal antibodies, Naveen Gurupatham Jesubalan and Anurag Singh Rathore (Abstract)
A non-EBA method to load unclarified feed onto a well packed chromatography column, Zuwei Jin, Zhou Sheng, and Huixin Xu (Abstract)
End to end continuous viral particle production and purification, Caryn Heldt, Michael J. Betenbaugh, Dylan Carman, Bradley Priem, Justin Sargunas, Taravat Sarvari, and Natalie Nold (Abstract)
Control strategy: Where dynamic perfusion meets savvy automation, Nikunj Sharda, Zeenashah Anderson, Carrington Edmunds, Jon a Coffman, Ujwal Patil, and Irina Ramos (Abstract)
Integrated biomanufacturing through volume-independent magnetic separation and model-based optimization, Sonja Berensmeier, Sonja Berensmeier, and Marko Tesanovic (Abstract)
Developing an enterprise-wide implementation strategy for Integrated Continuous Purification Implementation at Sanofi, Michael Coolbaugh, Chad Varner, Jon Forstrom, Jon Forstrom, Sumitava De, and Shashi Malladi (Abstract)
Synthetic spectral libraries for Raman model calibration, Louis Hellequin, Vicent J. Borràs, Patrick Romann, Jonathan Souquet, and Thomas K. Villiger (Abstract)
Scalable continuous flow zonal ultracentrifugation for purification of bionanoparticles, Viktoria Mayer; Madhusudhan Reddy Bobbili; and Patricia Centre of Industrial Biotechnology, Pereira Aguilar (Abstract and Presentation)
Implementation of a N-1 perfusion step in a continuous fed-batch mAb production process, Ronald Eimers (Abstract)
Advancing cost-effective antibody production: Integration of low-cost ion exchange resins, radial flow chromatography, and process intensification through integrated buffer making with chromatography, Sanjeev Saxena and Sanjeev Saxena (Abstract)
Multiple fill and drain operation: A promising strategy for cost reduction and sustainability in bioprocessing, supported by a high strength single-use film, Maria Mora, Diana Perez, Marisa Maher, Shannon Cleveland, and Hemant Garg (Abstract)
Study for cost-effectiveness of cell culture media in continuous manufacturing process, Yusaku Shimura, Naruki . Shibata, Kosuke Kuroda, and Ryuma Nagano (Abstract)
Application of ready-to-use raman calibration models in perfusion processes, Luis Ayala, Lisa Wolowczyk, Mona Bausch, Célia Sanchez, Johan Cailletaud, Fabrice Thomas, and Niklas Welzenbach (Abstract)
Improving perfusion performance via application of a perfusion-specific CLD workflow, Vince Balassi, Trissa Borgschulte, Sadie Sakurada, David Razafsky, Channing McLaurin, Amber Petersen, and Jana Mahadevan (Abstract)
Automated continuous multi-column chromatography capture step for a secreted protein produced in E. coli, Jürgen Beck, Markus Berg, Felix Schelberger, Benedikt Haslinger, and Rainer Hahn (Abstract)
Continuous purification of secretory IgA: From resin limitations to alternative ligand strategies, David Scheich, Rainer Hahn, Nico Lingg, and Alois Jungbauer (Abstract)
Automated sensor system for on-line monitoring of monoclonal antibody titer, Fernanda Rebellato Giordano Martim, Motasam Majedy, Sven Milton, Erik Martinsson, and Thuy Tran (Abstract and Presentation)
Model-based control of tangential flow filtration and multi column chromatography in a continuous bioprocess, Wolfgang Sommeregger and Felix Schelberger (Abstract)
Benefit-Risk Assessment of advanced continuous manufacturing technologies, Ushma Mehta (Abstract)
Sustainable integrated continuous antibody downstream processing using buffer intensification, Bernt Nilsson, Madelène Isaksson, Julius Klemens Lorek, and Niklas Andersson (Abstract and Presentation)
Mass transfer: A dual sparger approach for perfusion processes, Mauran Mahendra, Anthony Beaney, Colin Jacques, Natalia Papalamprou, Francis Cathal Dolan, and George Tilley (Abstract)
Extended recombinant adeno-associated virus production by continuous bioprocess in high cell- density perfusion bioreactors, Ye Zhang and Véronique Chotteau (Abstract)
Exploring the future of 500L scale hybrid continuous manufacturing, Shinsuke Kikuchi, Yusaku . Shimura, Emi Miyamoto, Kosuke Kuroda, Junki Nakasako, and Takanobu Tsukamoto (Abstract)
Advancing biopharmaceutical manufacturing: A functional prototype approach to integrated continuous biomanufacturing at lab-scale, Thomas Kruse, Elias Knöchelmann, David Pollard, and Markus Kampmann (Abstract and Presentation)
Impact of hollow fiber filter configuration on tangential flow filtration cell-retention performance in a continuous harvest CHO-based platform process, Rosemichelle Marzan, Jason Friedman, Iris Garcia, Ashley Baltes, and Kyla Yamashita (Abstract)
Enhancing biomanufacturing: A scaled-down continuous centrifuge for efficient cell harvesting and technology transfer, Michaela Dölle, Maxime Hervé, Anders Ekström, Staffan Königsson, Peter Thorwid, Per-Gustaf Larsson, and Véronique Chotteau (Abstract)
VMF: Disruptive Vibro® technology for continuous biomanufacturing processes, Jarno Robin (Abstract and Presentation)
Optimizing control parameters in continuous processes using particle swarm optimization: A case study on Ph, conductivity, and flow rate, Elias Knöchelmann, Oliver Stark, Luca Stähelin, Thomas Kruse, and David Pollard (Abstract)
Continuous cultures of recombinant CHO cells by a perfusion cell culture system using a tangential flow filtration module with hollow fiber membrane and a bearingless pump, Duk Jae Oh and Hyunwoo Kim (Abstract)
Raman monitoring perfusion bioproduction process of human pluripotent stem cells, Meeri Mäkinen and Veronique Chotteau (Abstract)
Advances in hybrid modeling for in silico optimization and supervisory control of perfusion cell culture processes, Gerben Zijlstra and Chris McReady (Abstract)
AAV harvesting using an asymmetric pore hollow fiber membrane in TFF mode: High product yield through stable cake layer formation, April Wheeler, Ranil Wickramasinghe, Rony Horax, Xianghong Qian, Xiaolei Hao, and Hironobu Shirataki (Abstract and Presentation)
Modeling and simulation of an integrated perfusion bioreactor with cell retention system, Karundev Premraj, Athul A S, Venkata Sudheendra Buddhiraju, and Venkataramana Runkana (Abstract)
Virus safety for continuous processing, Ruth de la Fuente, Mark Schofield, Kurt Boenning, and Nigel Jackson (Abstract)
Intensified manufacturing of therapeutic pre-miR-29b through continuous perfusion cultivations, Francesco Iannacci, Antonio Salza, Mattia Sponchioni, and Fani Sousa (Abstract)
Continuous perfusion process design enabled by facile pseudo-perfusion experimentation and metabolic modeling, Nikola Malinov, Marianthi . Ierapetritou, and Eleftherios. Papoutsakis (Abstract)
Flow-velocity gradient chromatography as a capture step for integrated continuous downstream process of biologics, Shuichi Yamamoto, Noriko Yoshimoto, and Fuminori Konoike (Abstract)
The innovative flow-through solution for continuous viral inactivation, Johannes Wortmeyer, Stuart Tindal, Karolina Meyer-Heinrichs, Lisa Lipski, Tobias Steinwedel, Chad Varner, Kevin Brower, Michael Coolbaugh, Akshat Mullerpatan, Vishwanath Hebbi, Mark Brower, Lara Fernandez Cerezo, Adrian Gospodarek, and Nuno Pinto (Abstract)
Non--Capture Antibody Purification (NCAP): Investigating the dual functionality of core shell technology, Anna Hermanoska, Razwan Hanif, Mariangela Spitali, and Chad Zhang (Abstract)
Continuous culture in cell line development: Applications for plant secondary metabolite production, Lukas Leibetseder, Janos Bindics, and Johannes Buyel (Abstract)