Optimization of scalable rAAV production for gene therapy – Leveraging at-line amino acid measurements for bioprocess modeling-driven approaches

Authors

Graziella Piras, 908 Devices, Inc., USAFollow
Milla Neffling, 908 Devices, Boston, MA
John Joseph, Massachusetts Institute of Technology, Center for Biomedical Innovation
Tam N T Nguyen, BioNtech SE, Cambridge, Massachusetts
Ji Young Anderson-Czajkowski, 908 Devices, Boston, MA
Scott Miller, 908 Devices, Boston, MA
Graziella Piras, 908 Devices, Boston, MA
Anthony J. Sinskey, Massachusetts Institute of Technology, Department of Biology
Richard D. Braatz, Massachusetts Institute of Technology, Department of Chemical Engineering
Jacqueline Wolfrum, Massachusetts Institute of Technology, Center for Biomedical Innovation
Paul W. Barone, Massachusetts Institute of Technology, Center for Biomedical Innovation
Stacy L. Springs, Massachusetts Institute of Technology, Center for Biomedical Innovation

Conference Dates

February 4 - 8, 2024

Abstract

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Recommended Citation

Graziella Piras, Milla Neffling, John Joseph, Tam N T Nguyen, Ji Young Anderson-Czajkowski, Scott Miller, Graziella Piras, Anthony J. Sinskey, Richard D. Braatz, Jacqueline Wolfrum, Paul W. Barone, and Stacy L. Springs, "Optimization of scalable rAAV production for gene therapy – Leveraging at-line amino acid measurements for bioprocess modeling-driven approaches" in "Advancing Manufacture of Cell and Gene Therapies VIII", Fernanda Masri, Cytomos, United Kingdom; Carolyn Yeago, CY Solutions LLC, USA; Gargi Maheshwari, BMS, USA; John Moscariello, BMS, USA Eds, ECI Symposium Series, (2024). https://dc.engconfintl.org/cell_gene_therapies_viii/22