September 15-19, 2019
Whistler Resort
Whistler, British Columbia, Canada

Editors:   Huimin Zhao, University of Illinois at Urbana-Champaign, USA
  John Wong, Pfizer, USA

The articles for these proceedings are not peer-reviewed.

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Controlling the fatty acid hydroxylation regioselectivity of CYP152A1 (P450Bsb) by active site engineering, Lucas Hammerer, Michael Frieß, Wolfgang Kroutil, Jeyson Cerne, Georg Steinkellner, Karl Gruber, Koenraad Vanhessche, Thomas Plocek, and Christoph K Winkler (Abstract)

Computational study of the structure-function relationship of an artificial Friedel-Crafts alkylase, Lur Alonso-Cotchico, Lara Villarino, Gerard Roelfes, Jean-Didier Maréchal, and Agustí Lledós (Abstract)

Understanding enzymes specificities as a tool for cofactor engineering, Madhuri Gade, Alejandro Villar-Briones, Paola Laurino, and Colin J. Jackson (Abstract)

A structure-based approach to control the size and linkage-type of sucrose derived alpha-glucans, Magali Remaud-Simeon (Abstract)

Engineering the biosynthesis of non-ribosomal peptides, Mark Jonathan Calcott and David Ackerley (Abstract)

Identification and engineering of a Dye-Decolorizing Peroxidase (DyP) for C—C-bond forming carbene-transfer reactions, Martin Weissenborn (Abstract)

Purification and pressure dependence of alanine racemase from the psychro- piezophilic bacterium shewanella violacea DSS 12, Minoru Tanigawa, Keisuke Itabashi, Katsushi Nishimura, Mayumi Tokuhisa, Miya Koike, and Chiaki Kato (Abstract)

Cloning and expression of a serine racemase gene homologue of the green alga Chlamydomonas reinhardtii and characterization of the gene product, Miya Koike, Minoru tanigawa, and Katsushi n nishimura (Abstract)

Exploring the potential of ancestral phenylalanine/tyrosine ammonia-lyases for therapeutic applications, Natalie Marie Hendrikse, Albin Holmberg Larsson, Per-Olof Syrén, Sergei Kuprin, Erik Nordling, and Stefan Svensson Gelius (Abstract)

Molecular packaging of biocatalysts using a robust protein cage, Nikola Loncar, Henriette J. Rozeboom, Marco W. Fraaije, Linda E. Franken, and Marc C. A. Stuart (Abstract)

Preparation of pectate lyase/Cu3(PO4)2 hybrid nanoflower and its catalytic performance as an immobilized enzyme, Pan Wu, Guimin Zhang, and Feifan Luo (Abstract)

Fungal peroxygenase chimera identified by sub-domain shuffling and split-gfp reveal retained activity and altered specificity, Pascal Püllmann and Martin J. Weissenborn (Abstract)

A retrobiosynthetic approach to generate terpene-derived polymers, Per-Olof Syrén (Abstract)

Engineering of a specific CYP450 for an industrial process shows 700-fold increase in activity with Kcat of 6.2 s-1 - Residues causing Hydrogen Migration and Double Hydrogen Abstraction at Δx Carbon identified by Quantum Mechanics revealed to be the game, Lalitha Roopa, Gladstone Sigamani, Roopa .L, and Akshai. P.S (Abstract)

Enabling medium-chain fatty acid production in yeast via high-throughput MALDI MS- based enzyme engineering, Pu Xue, Tong Si, and Huimin Zhao (Abstract)

Engineering alcohol oxidases for substrate scope and their application in flow and cascade biocatalysis, Rachel Heath, Matthew Thompson, Jeremy Ramsden, William Finnigan, Nicholas Turner, and Sebastian Cosgrove (Article)

Using protein engineering to accelerate implementation of continuous biocatalysis for API synthesis, Rowan Lindeque and John M. Woodley (Abstract)

Innov’SAR: A new approach for protein engineering and screening, Rudy Pandjaitan, Nicolas Fontaine, Matthieu Ng Fuk Chong, and Frederic Cadet (Abstract)

A data-driven approach for exploiting enzyme promiscuity as a means to predict novel biochemical reactions, Sanjan TP Gupta, Parameswaran Ramanathan, and Jennifer L. Reed (Abstract)

Engineering enzymes with non-canonical active site functionality, Sarah L. Lovelock, Ashleigh J. Burke, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Amina Frese, and Anthony P. Green (Abstract)

Enzyme engineering of fungal-derived FAD-GDH by circular permutation, Satoru Ishihara, Kyoichi Nishio, Satoshi Koikeda, and Stefan Lutz (Abstract)

Application of directed divergent evolution strategy in natural product biosynthesis, Shuang-Yan Tang, Wei Chen, and Jun Yao (Abstract)

A technology platform for in vitro transcription and translation of enzymes in micro compartments, Silvia Calabrese, Martin Schulz, Felix von Stetten, Nadine Borst, Sophia Probst, Gerassimos Kolaitis, and Joseph Sperl (Abstract)

Design strategy for creating catalytically active metal binding proteins, Stacey Gerben, Ralph Cacho, and David Baker (Abstract)

Evolution of the ThDP dependent pyruvate dehydrogenase E1 subunit for the conversion of long chain aliphatic ketoacids, Stefan R. Marsden, Duncan G. G. McMillan, and Ulf Hanefeld (Abstract)

Engineering of halohydrin hydrogen-halide-lyase (H-lyase) for efficient L-carnitine production, Takanori Akiyama, Fumiaki Watanabe, and Wataru Mizunashi (Abstract)

Improved biomass conversion with Trichoderma reesei beta-glucosidase Cel3A engineered for broader substrate specificity, Thijs Kaper, Amy Liu, Brad Kelemen, Zach Beck, Pim van der Kley, Slavko Kralj, Henrik Hansson, Mats Sandgren, and Nils Mikkelsen (Abstract)

Substrate promiscuity in evolved Alcohol Dehydrogenase A (ADH-A), Thilak Reddy Enugala and Mikael Widersten (Abstract)

Unravelling the relationship between substrate selectivity and primary sequence of UDP-glycosyltransferases, Tiia Kittilä and Ditte Hededam Welner, (Abstract)

Oligopeptides production by a method involving an enzymatic reaction and a subsequent chemical reaction, Tomoko Abe, Kenta Kobayashi, Kiwamu Shiiba, and Michihiko Kobayashi (Abstract)

A non-natural Nicotinamide cofactor for biotransformation at extreme conditions, Volker Sieber (Abstract)

Designing de novo retroaldolase catalysts, Yakov Kipnis and David Baker (Abstract)

Tailored biosynthesis of pseudosugars against diabetes by repurposing the promiscuous microbial enzymes, Yan Feng and Li Cui (Abstract)

Genetically encoded biosensor for engineering branched-chain higher alcohol production pathway in saccharomyces cerevisiae, Yanfei Zhang and José L. Avalos (Abstract)

Newly discovered enzymes and cascades for the determination of amino acids, Yasuhisa Asano (Abstract)

Engineering an aldehyde dehydrogenase via structure based directed evolution for enhancement of 3-hydroxypropionic acid production, Ye Seop Park, Un Jong Choi, Tae Hyeon Yoo, Hoai Nam Nguyen, and Sunghoon Park (Abstract)

A novel C-terminal protein degron identified in bacterial aldehyde decarbonylases using directed enzyme evolution, Yilan Liu, Jinjin Chen, Radhakrishnan Mahadevan, Anna Khusnutdinova, Kevin Correia, and Alexander F. Yakunin (Abstract)

Enantiocomplementary synthesis of chiral alcohols combining photocatalysis and whole-cell biocatalysis in a one-pot cascade process, Yongzhen Peng, Jian Xu, Qi Wu, and Xianfu Lin (Abstract)

Substrate specificity of tRNA-dependent amide bond-forming enzyme, Yoshimitsu Hamano (Abstract)

Engineering of penicillin G acylases for the production of β-lactam antibiotics on an industrial scale, Young Sung Yun (Abstract)

Fusing enzymes to transcription activator LuxR for the rapid creation of metabolite sensors, Yuki Kimura, Shigeko Kawai-Noma, and Daisuke Umeno (Abstract)

Expression and characterization of keratinase from Deinococcus gobiensis I-0, Zhengfu Zhou, Xiuxiu Geng, Jin Wang, and Min Lin (Abstract)

Engineering T1 lipase for degradation of poly-(R)-3-hydroxybutyrate, Normi Mohd Yahaya, Rauda A a Mohamed, Mohd Basyaruddin Abdul Rahman, Adam Thean Chor Leow, and Abu Bakar Salleh (Abstract)

Development and application of novel engineered transaminase panels assisted by in- silico rational design for the production of chiral amines, Daniel F.A.R. Dourado, Stefan Pohle, Stefan Mix, Thomas S. Moody, Derek J. Quinn, Jill Caswell, Alexandra T. P. Carvalho, and Meilan Huang (Abstract)

Purification and characterization of a novel alginate lyase from the marine bacterium bacillus sp. Alg07, Peng Chen, Yan Men, Yan Zeng, and Junjun Yan (Abstract)

In silico approach to better understand the role of active site residue, Sindrila Dutta Banik, Shivakumar Venkataraju, Naveen Kulkarni, and Suvamay Jana (Abstract)

Deletion studies for elucidating the role of Streptomyces griseus ChiC non-catalytic residues, Ayokunmi Oyeleye, Adam Thean Chor Leow, Noor Baity Saidi, and Normi M. Yahaya (Abstract)

Improving the catalytic activity of isopentenyl phosphate kinase through protein coevolution analysis, Xuerong Xing (Abstract)

Improving the thermostability of glutamate decarboxylase by consensus mutagenesis, Jun Huang (Abstract)