March 30 - April 3, 2025
Porto, Portugal
| Chairs: | Eli Keshavarz-Moore, University College London |
|---|---|
| Thomas Sauer, Sanofi |
25 conference program - Microbial Engineering III: New Generation of Cell Factory to Meet the Future Challenges and Seize New Opportunities, Eli Keshavarz-Moore and Thomas Sauer (Article)
Is microbial production a good option for exceptionally low cost monoclonal antibodies for global access?, Vijay Yabannavar (Abstract and Presentation)
A predictive tool to design the protein folding machinery in Escherichia coli, Duygu Dikicioglu and Fairooza Alam (Abstract)
Numaswitch, a novel biochemical platform for efficient peptide and protein production, Christian Schwarz, Roxann Guerrette, and Bach-Ngan Wetzel (Abstract and Presentation)
Next generation Komagataella phaffii strain engineering by CRISPR- mediated targeted integration, Daniel Degreif, Elena Ivanova, and Paul Ramp (Abstract)
Towards a more cost-effective and sustainable production of therapeutic proteins, David Pollard and Behnam Partopour (Abstract and Presentation)
Purecoli: An optimized microbial chassis delivering a holistic solution for therapeutic protein manufacturing, Erik Nordwald, Tyler Telander, Sigma Mostafa, Julius Johnson, and Sean Mcloughlin (Abstract)
Revolutionizing RNAi therapeutics manufacturing with enzymes, Stefan Lutz (Abstract)
Hormonema carpetanum: From juniper tree to patient- the story of an endophytic fungi and the oral treatment of vulvovaginal candidiasis, Ben Huckle (Abstract)
Role of microbial technology in the bioeconomy: An overview, Barry Buckland (Abstract)
Glycoengineering and production of therapeutic and vaccine proteins in the filamentous fungus Thermothelomyces heterothallica C1, Markku Saloheimo, Anne Huuskonen, Mark Emalfarb, Noelia Valbuena Crespo, Ronen Tchelet, Georg Schmidt, Waltteri Hosia, Mari Mäkinen, Marilyn Wiebe, and Marika Vitikainen (Abstract)
Engineering archaeal ferritin nanoparticles for vaccine development via tyrosinase-mediated conjugation, Margarida Queluz Rodrigues, Mónica Thomaz, António Roldão, and Paula M. Alves (Abstract)
Streamlining plasmid DNA manufacturing for advanced therapy manufacturing, Salomé Magalhães and Eli Keshavarz-Moore (Abstract)
Integration of microbial processes in a flexible multi-modality vaccine manufacturing facility, Bruno Tricoire (Abstract)
Revitalize Escherichia coli platform to support biologics development and manufacturing of new modalities, Sam Zhang (Abstract)
Use of acetic acid as a carbon source for food production, Carsten Hjort (Abstract)
Biocatalysis of petroleum replacement molecules from biomass wastes, John Love (Abstract)
Making biology easier to engineer, together, Patrick Boyle (Abstract)
From plastic to paper: A novel microbial factory for conversion of PET monomers, Sierin Lim, Jingyuan Wang, and Rupali Reddy Pasula (Abstract)
Development of tools for the molecular engineering of lignocellulolytic anaerobic fungi, Kevin Solomon (Abstract)
Closing the doors of the peroxisome: Towards synthetic methylotrophy, Xavier Farge, Olivia Bettstein, Özge Ata, Stéphanie Heux, and Diethard Mattanovich (Abstract)
Improving the efficiency of organic acid production from one-carbon substrates in Komagataella phaffii through enzyme and metabolic engineering, Charles Moritz, Özge Ata, Clemens Peterbauer, and Diethard Mattanovich (Abstract)
Rapid, high-yield, & flexible biomanufacturing for biopharmaceuticals, health, wellness, food, & nutrition, Mark Emalfarb, Ronen Tchelet, and Noelia. Valbuena (Abstract)
Optimization of protein production in yeast, Xiaochun Fan (Abstract)
CO2 sequestration by microbial rock weathering: Overcoming process limitations with genetic engineering, Neil Dalvie; Michael Springer; Jan-Tobias Boehnke; Amogh Jalihal,; and Pamela Silver (Abstract)
Bridging the gap from AI to application: Biocatalysis meets cell-free systems, Rahul Singhvi (Abstract)
Accelerating the transition to bioalternatives through systems-level engineering, Christine Santos (Abstract)
Microbial synergy powers anaerobic conversion of carbon monoxide into bioplastics, Diana Sousa, Martijn Diender, and Timon Ruano Torres (Abstract)
Engineering chimeric regulators to unlock non-native substrate assimilation, Stephanie HEUX, Yannick Bernard-Lapeyre, and Cláudia M. Vicente (Abstract)
Enhancing isobutanol production by Klebsiella pneumoniae using synthetic biology tools, Frank Baganz, Jian Hao, and Jiaming Chen (Abstract)
The expanding world of cell-free biotechnologies: From targeted therapeutics to carbon-negative biochemicals, James Swartz (Abstract)
Advanced microbial engineering for the production of human milk oligosaccharides, Getachew Molla, Niels Banke, and Ted Johanson (Abstract)
Engineering Yarrowia lipolytica for sustainable lipid production: A scalable alternative to edible and cosmetic oils, Leonardo Rios Solis (Abstract)
Are we there yet? A maturity model for continuous process monitoring and learning in biologics manufacturing, Jack Prior (Abstract and Presentation)
Advancing metabolic engineering and modelling with AI, Thomas Abeel (Abstract)
Engineering the next generation of microbial production strains for biologics, Markus Mund (Abstract)
Host-agnostic DNA design with generative AI for microbial engineering, Rahmi Lale, Lisa Tietze, Maxime Fages-Lartaud, Thea Isabel Bakken, and Gurvinder Singh Dahiya (Abstract)
Engineering inducible autolysis in E. coli for large scale intracellular bioproduct recovery, Kyle Jonsson, Darren Nesbeth, and Eli Keshavarz-Moore (Abstract)
Toward augmenting the global biomanufacturing supply chain with decentralized cell-free protein expression, Keith Pardee, Matthews Q, Bayat P, Iwe I, Vigar J, Duplat D, Nazly B, Bolivar P, Pessoa R, Cranmer L, Masum F, Fobel R, Tinafar A, Cicek S, Guo Y, Talebi S, Wu A, Yan C, Singh S, Norouzi M, Sinton D, Mazzuli T, Gonzalez CR, Pena L, Federici F, Simchi M, and Ribeiro da Silva SJ (Abstract)
A scalable, eukaryotic cell-free protein production technology accelerating vaccine and therapeutic development, Charles Williams, Jorge Armero-Gimenez, Ridhima Gomkale, Maja Lieven, Hannes Juergens, and Ricarda Finnern (Abstract)
Harnessing cell-free protein synthesis technology for the production of glycosylated full-length antibodies using bacterial lysates, Rochelle Aw, Derek Wong, and Michael Jewett (Abstract)
E. coli cell-free protein synthesis platform for rapid Adeno-associated 5 virus-like particle production, Danielle Deuker (Abstract)
New modalities in medicine and curative therapies, Hari Pujar (Abstract)
Establishing a biosensor for high-throughput screening of isobutanol producing strains, Jiaming Chen, Xizi Wang, and Frank Baganz (Abstract)
Multiparameter sensors and DO sensor pills for shake flasks: removing black boxes for improved bioprocess development, Hendrik Schmidt and Dr.stina Dickmeis (Abstract)
Complex waste stream valorization through combined enzymatic hydrolysis and catabolic assimilation by Pseudomonas putida, Micaela Chacon, Guadalupe Alvarez Gonzalez, Piya Gosalvitr, Adokiye Berepiki, Karl Fisher, Rosa Cuéllar-Franca, and Neil Dixon (Abstract)
Characterising plasmid DNA release and impurity removal in continuous alkaline lysis, Jay Stonehouse, Will Bryan-Smith, and Eli Keshavarz-Moore (Abstract)
Enhancing tartaric acid metabolization in probiotic Escherichia coli Nissle 1917, Greta Emma Katharina Kleinert, Matthias Wohlleben, Lars M. Blank, Martin Zimmermann, and Sebastian Köbbing (Abstract)
Microbial engineering of extremophiles for the discovery of bioactive molecules, Barbara A ndrews, Carol Jara, Juan.A. Asenjo, and Diego Sandoval (Abstract)
Establishing Aureobasidium pullulans as platform organism for the biosynthesis of natural products - Developing tools for efficient genetic manipulation, Marielle Driller, Adrian Enrique Gadar-Lopez, Marie Dielentheis-Frenken, Karla Stein, Ana Calheiros de Carvalho, Pablo Cruz-Morales, Jay D Keasling, Kongens Lyngby, Lars M. Blank, and Till Tiso (Abstract)
Use of radial flow chromatography for cost effective, large scale isolation of lactoferrin from skim milk or precision fermentation for infant nutrition, Sanjeev Saxena (Abstract)
Exploiting Aureobasidium as platform organism for the circular bioeconomy, Karla Stein, Marielle Driller, Till Tiso, and Lars M. Blank (Abstract)
Process design for enhanced polyol lipid production using bio-based substrates with Aureobasidium pollulans, Philipp Kohl, Marie R.E. Dielentheis-Frenken, Frederick Haala, Till Tiso, and Lars M. Blank (Abstract)
Development of enzymes from extremophiles for the degradation of plastics and potential generation of useful metabolites, Juan A. Asenjo, Anamaria Daza, Antonia Aste, Diego Sandoval, and Barbara Andrews (Abstract)
Integrated decoupled bioprocess and cell recycling system of recombinant Pseudomonas putida KT2440 for trans-cinnamic production, Sompot Antimanon, Sheila I. Jensen, and John M. Woodley (Abstract)
Identification and characterisation of aromatic acid transporters via combined syntenic analysis and genetically encoded biosensor screening, Philip Le Roy, Micaela Chacon, and Neil Dixon (Abstract)
A multifaceted approach for bioprocess optimization, modelling and integration: recombinant growth factor production on upcycled spent cell culture media, Dave Siak-Wei Ow, Prashant Mainali, Juliana Rizal, Jun Ping Quek, Ng Say Kong, Zhang Wei, and Wong Fong Tian (Abstract)
Maximizing the potential of SYNTHORINTM technology: sterilization conditions impact fidelity of semi-synthetic proteins, Jacqueline Becker, Yali Zhang, Sebastian Scholz, and Daniel Degreif (Abstract and Presentation)
Application of a fluorescent H2O2 biosensor to identify and mitigate intracellular redox stress, Jennifer Staudacher, Valentin Schachinger, Victor Mendes Honorato, and Brigitte Gasser (Abstract)
Engineering of a novel E. coli strain for sustainable, end-to-end continuous manufacturing of biomolecules, Florian Simon, Patrick Stargardt, Natalia Danielewicz, Florian Weiss, Johanna Berein, Gerald Striedner, and Jürgen Mairhofer (Abstract)
Preclinical development of a VHH-ADC using the PET platform, Diane Retallack, Nathanial Howitz, Mathew Samano, Michael Bacica, Elizabeth Orchard, and Russell Coleman (Abstract)
Exhaust concept for scalable single-use fermenter and high-demanding microbial cultivations, Jens Rupprecht (Abstract and Presentation)
POP-OUT-plasmid platform for antibiotic free production of recombinant protein, Ritu Ghosh, Marje Kasari, and Villu Kasari (Abstract)
Accelerating plasmid production process development using a scale-down model of E. coli fermentation in the Ambr250, Tracey Dinh (Abstract)
Encapsulins unpacked: a scalable bioprocess for high-yield production, Ferdinando Sereno, Andrea Rayat, and Stefanie Frank (Abstract)
Comparison of single-use and steel fermentors for malaria vaccine expression, Jason Brown, Vu Nguyen, and David L. Narum (Abstract and Presentation)
Development of a chemically defined media for Escherichia coli, leveraging learnings from traditional peptone-based media, Massimo Ferretti (Abstract)
Screening of K. phaffii using novel shake flask technology, Shannon Gulvin, Lauren Cordova, Zhiguo Liu, and Thomas R. Blanda (Abstract)
The future of microbial manufacturing: a chemically defined E. coli-based medium and feed for plasmid and protein production, Stacy Holdread, Neelanjan Sengupta PhD, James W. Brooks, Juliet Macharia, Mercy Arkorful, Nathan Cordell, Allison Bernard, and Alex J Jones (Abstract)
FinaXpress - The next generation E. coli platform for cost-effective production of hard-to- express, disulfide-bonded proteins, Renaud Jacquemart, Andrew Lees, and Natalia Oganesyan (Abstract)