Ultra-sensitive and portable organic electrochemical transistors for noninvasive saliva glucose monitoring
Conference Dates
May 15-18, 2023
Abstract
Abstract: Currently, there is no available approach for non-invasive glucose monitoring in the human saliva fluid because of its low glucose density, complex salivary composition, and poor blood correlation. Here, we report a non-invasive, ultra-sensitive, enzymatic stable, and continuous saliva glucose monitoring system based on an organic electrochemical transistors (OECTs), which can be real-time and wirelessly monitored and analyzed saliva glucoses with a portable meter and a mobile smartphone. The system presents a stable sensing performance in monitoring saliva glucose for over 12 hours with high sensitivity (1 × 10-9 M). The clinical trials results for saliva glucose showed a monoclinic relationship between the fasting glucose levels of saliva and blood with little deviation (~10%) in 102 human samples in different gender/age groups of with and w/o diabetics. A delay of glucose level in saliva to blood with a more complicated relationship was obtained in continuous saliva glucose measurement. This approach paves the way to clinically non-invasive and continuous glucose monitoring based on thin film transistors.
Please click Download on the upper right corner to see the full abstract.
Recommended Citation
Zeyu ZHAO and Feng YAN, "Ultra-sensitive and portable organic electrochemical transistors for noninvasive saliva glucose monitoring" in "Semiconductor Technology for Ultra Large Scale Integrated Circuits and Thin Film Transistors (ULSIC VS TFT 8)", Y. Kuo, Texas A&M University, USA Eds, ECI Symposium Series, (2022). https://dc.engconfintl.org/ulsic_vs_tft_8/11