April 27 - May 2, 2025
Tucson, AZ
| Chairs: | A Khetan, BMS |
|---|---|
| Marcella Yu, Gilead | |
| Mike Betenbaugh, Johns Hopkins University |
Flexible deployment of advanced automated tools for cell culture process development and beyond, Chris Lowe, Gioia Tuozzolo, Leo Karmiy, Zach Houle, and Anuradha Ponugoti (Abstract)
Revealing the impact of extracellular vesicles on cell culture performance: An overlooked component in conditioned media, Hong Nguyen, Eleftherios T. Papoutsakis, and Kelvin H. Lee (Abstract)
Targeting bottlenecks in recombinant adeno-associated virus production: Optimizing gene expression for improved content ratio, Sofia Alfieri and Kelvin Lee (Abstract)
Elucidating Aggregation Mechanisms of Multispecific Antibodies, Hillary Miller, Myrna Yehia, Harsha Gunawardena, Lauren Kraft, Bo Zhai, Hirsh Nanda, Tom Kelly, Partha Chowdhury, and Michael Poltash (Abstract)
Process development and titer improvement for transient production of AAV, Michael Gillmeister, Jeanne Branson, and Don Startt (Abstract)
Next generation torture chamber: Effect of extensional flows on cells and high-density culture results, Hyeon Choe, Michae l Mollet, and Jeffrey J. Chalmers (Abstract)
Site-directed integration platform can support industry-relevant titers while reducing CLD time and effort, Michelle Sabourin, Suet Yan Kwan, Ann Lovgren, Daniel Ivansson, Johanna Rohde, Prajakta Khalkar, and Andreas Jonsson (Abstract and Presentation)
Improvement of cellular mechanisms via protein hydrolysate supplementation, Brandon Wrage, Brittany Patterson, Angel Varela-Rohena, and Salewa Akande (Abstract and Presentation)
iCHO3K: A new community-driven genome-scale metabolic model network reconstruction of Chinese hamster ovary cell, Dong-Hyuk Choi, Pablo Di Giusto, Athanasios Antonakoudis, Pierrick Craveur, Vikash Gokul, Meiyappan Lakshmanan, Anne Richelle, Nathan E. Lewis, and Dong-Yup Lee (Abstract)
Engineering high-yield, stable packaging and producer cell lines for scalable lentivirus manufacturing, Adam Carcella, Michelle Chang, Adam Carcella, Jeremy Gam, Jeff McMahan, Joseph Collins, and Paulena Lieske (Abstract)
Engineering UGCG-overexpressing stable cell lines for enhanced viral vector production, Marzia Rahimi, Lars Keld Nielsen, and Jesús Lavado García (Abstract)
Leveraging metabolic models to transfer knowledge from fed-batch to continuous cultures, Mariana Monteiro, Stacy Bediako, Gregory Nierode, Ricardo Tecson, Pavlos Kotidis, and Cleo Kontoravdi (Abstract)
A modular platform of reconstructive 3D cell models of tumor microenvironments to evaluate antibody-based therapies, Margarida Serra, Giacomo Domenici, Catarina Brito, Catarina Freitas, Nádia Duarte, Gonçalo Trindade, Isabella Ramella Gal, Sofia Batalha, and Nuno F. Lopes (Abstract)
Overcoming oxidative cellular senescence in high-density cell bioreactor for viral vaccine production improving the productivity, Hsian-Yu Wang and Yu-Jing Zeng (Abstract and Presentation)
Deciphering the individual and interactive effects of media selection and type of production process on the stability of biopharmaceutical drugs, Rama Bhupal Reddy Kandula, Vikas Chandrawanshi, Sampath Kumar Veeramally, Suman Bandyopadhyay, and C Nirmala Raju (Abstract)
Digital twin modelling of mammalian cell culture systems for biopharmaceutical manufacturing, Li Qin, James Savery, Matthew Cheeks, Suzanne S. Farid, and Stephen Goldrick (Abstract)
Leveraging MFA and multi-omics to modulate fucosylation and uncover underlying mechanisms, Ping Xu, Marcus-Allen Nicolas, Mahalia Serrano, Anurag Khetan, Lakshmi Kandari, and Alberto Galvan (Abstract)
Enhancing process development through knowledge transfer across clones and scales with platform cell model (PCM), Mehran Rafigh, Jakob Kirch, Joachim Schmid, and Bruno Morabito (Abstract)
Modulation and control of antibody glycosylation: An experimental and computational study, Susan Sharfstein, Ranya Pranomphon, Sofia Gialamoidou, Montarop Yamabhai, and Ioscani Jiménez del Val (Abstract and Presentation)
Mixture Design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production, Pol Hulsbus i Andreu, Konstantina Tzimou, Ece Bahar Yildirim, Jesús Lavado-García, and Lars Keld Nielsen (Abstract)
Tunable-laser NIR spectroscopy enables robust prediction of process attributes in mammalian cell cultivations without prior model training, Claes Nymand Nilsson, Bryan c. Hassell, Mats Åkesson, Jeppe Hagedorn, and Lars Poulsen (Abstract)
Integrating development, manufacturing, and regulatory considerations into advanced therapy medicinal products (ATMPs), Tiffany Rau (Abstract)
Production process development in suspension HEK293 for AAV vectors to improve productivity and quality attributes, Alicia Coombs, Jill Zhang, Andrew D. Tustian, Hanne Bak, and Jason Saunders (Abstract)
Assessing the impact of selective pressures on the genetic and epigenetic landscape of HEK293 cells used for rAAV production, Nikolaus Virgolini, Georg Smesnik, Alessandra Vernasca, Astrid Dürauer, Nicole Borth, and Alexander Molin (Abstract)
Improved detection of high-risk host cell proteins through spectral library construction for Chinese hamster-derived cell cultures, Tomoko Matsuda, Norichika Ogata, Noriko Yamano-Adachi, and Takeshi Omasa (Abstract)
Controlling Rep gene expression using synthetic biology tools, Emily Doleh and Mark Blenner (Abstract)
Optimizing biroeactor scale-up: AbbVie's comprehensive approach for scaling cell culture bioreactors from lab to large-scale, Anisur Rahman, Karna. Shah, and Nicholas. Abu-Absi (Abstract)
Applying 13C isotope tracing to elucidate CHO cell metabolism and composition, Bradley Priem, Xiangchen (Harry) Cai, Maciek Antoniewicz, and Michael Betenbaugh (Abstract)
Enhancing the productivity of an intensified process by optimizing feed composition for efficient cell metabolism, Lynn Theprungsirikul, Manos Tzortzakakis, Julia Edwards, Ricardo Romero Moreno, Jerry Eriksson, George Chacko, and Guru Thuduppathy (Abstract)
Optimizing T-cell manufacturing with a high-performance medium free of animal derived components, Joanna Kern, Lauren Kapus, Megan Logan, Evan Zynda, Michael Bruno, Anna Hachmann, and Kyle Zastrow (Abstract)
Controlling and applying the lactate shift for bioprocess monitoring and bioproduction improvements, Yu-Jun Hong and Maciek Antoniewicz (Abstract)
Streamlining bioprocesses by converting a dual-feed into a single-feed system with peptides, Zach Demorest, Johanna Peters, Stephan Brinkmann, Tomislav Trescec, Anne Benedikt, Christian Keßler, and Christina Jost (Abstract)
Transcriptomic analysis of recombinant CHO cell lines in response to endoplasmic reticulum stress inducing agents, Priya Mishra and Sarika Mehra (Abstract)
Mechanistic modeling of recombinant adeno-associated virus production in synthetic cell lines, Prahalad Srinivasan, Yen-An Lu, Wei-Shou Hu, Han-Jung Kuo, Yu-Chieh Lin, and Qi Zhang (Abstract)
Scalable 3D scaffold-based bioreactor platform for exosome research, development, and GMP manufacturing, David Sergeant, Roland HUBAUX, and Michael FRANCOTTE (Abstract)
Approaches for scale-down model qualifications using ambr250 high-throughput bioreactor for process characterization, Shaunak Uplekar, Matthew Johnsrude, Quan Zhou, Sigma Mostafa, Leslie Wolfe, and Kirsten Dysinger (Abstract)
Optimizing fed-batch feeding strategy using metabolic flux analysis and Raman spectroscopy, Woo Suk Ahn, Bonnie McAvoy, Canghai Lu, Lia Tescione, Alan Eilertson, and Michael Hill (Abstract)
Development of scalable clarification step for extracellular vesicles by using tangential flow depth filtration (TFDF) system, Lauren Torres (Abstract and Presentation)
Implementation of a multi-omics systems biology methodology for CHO based cell culture process development and product quality enhancement, Pubali Banerjee, Gioia Tuozzolo, Chrisina Alves, Christopher Barton, Johnathon Li, and Kyle McHugh (Abstract)
AOF peptones in cell culture media for viral vaccine manufacturing, James Brooks, Saranya Chitturi, Wen-Yang Tsai, Ashwin Gurunathan, Matt Rosecrans, Bilal Mughal, Stacy Holdread, and Syed Muaz Khalil (Abstract)
Development and scale-up of a novel adenovirus production process, Greg Bremer, Deborah Pano, Daniel Leblanc, Patrick Grumbach, Anxhela Kole, Deborah Pano, and Gregory Bremer (Abstract)
Comparative analysis of critical quality attributes of lentivirus across three production processes, Brianna Jayanthi, Paulena Lieske, Kevin Smith, Martin Carcamo, Ta Hang, Imroz Ghangas, Manali Desai, Adam Carcella, and Michelle Chang (Abstract)
Development of an apoptosis-resistant CHO cell line for biopharmaceutical production, Camila Orellana, Javier Bravo, Claudia Altamirano, Mauro Torres, and Alan Dickson (Abstract and Presentation)
Demonstrating key processes of the T Cell therapy workflow in chemically defined media, Katsuko Sato, Shahram Shahabi, Anastassia Tselikova, and Chandana Sharma (Abstract and Presentation)
AMBIC: An I/ucrc bringing together academia, industry, and government to progress pre- competitive biopharmaceutical Research, Edward Ma, Bradley Priem, Junneng Wen, Michael Betenbaugh, Justin Sargunas, Delia Lyons, and Luhong He (Abstract)
Bioprocess development for influenza A universal vaccine with chimeric hemagglutinin viruses, Eduard Puente Massaguer, Michael J. Scherm, Florian Krammer, and Robert Hoelzl (Abstract)
Enhancing glycan quality prediction in therapeutic antibodies through integrated hybrid modeling, Juan Camilo Gonzalez Rivera, Peter Onyskiw, Lakshmi Kandari, Gloria Li, Anurag Khetan, Chun Shao, Li Tao, Monica Milman, and Mahalia Serrano (Abstract)
Reconstructing the mammalian secretory pathway: secRecon as a fundamental tool for protein secretion research, Pablo Di Giusto, Helen Masson, Jasmine Tat, Athanasios Antonakoudis, Anne Richelle, and Nathan E. Lewis (Abstract)
Improving cell culture media preparation through automation and digitalization, Thomas Fletcher, Kaitlynn Bayne, Chris Cline, Scott Bailey, Joshua Southern, Sharyn Farnsworth, and Mark Patton (Abstract)
A cost effective and flexible approach towards tubespin bioreactors automation and accessibility, Kim Le, Kevin Trickey, Mark Juhas, and Allison Gablin (Abstract)
Modulation of mAb productivity and quality using automated multivariable control of perfusion bioreactor, Jaeweon Lee, Tom Bertalan, Zhao Wang, and Seongkyu Yoon (Abstract)
Leveraging the biomimetic Expansify™ gas permeable petri dish for cell therapy, Colin Cook, Austin Santiago, Seonah Kang, Shyambabu Chaurasiya, Hector Santiago, Nicholas Scianmarello, Gabriel Zwillinger, Kurt Yanagimachi, Hai Li, Yuman Fong, and Christopher Thanos (Abstract)
Cellular response and hydrodynamic stress adaptation of CHO cell lines by exposure to resonant acoustic mixing, Mauricio Trujillo-Roldan, Fernando D. . Montalvo-Sandoval, and Norma A. Valdez-Cruz (Abstract)
Comparative proteomic study of the enriched mitochondrial fraction of antibody- producing CHO cells, Norma A. Valdez-Cruz, Miguel A. Robles-Román, Mauricio A. Trujillo-Roldán, Saumel Pérez-Rodríguez, Octavio T. Ramírez, Bjørn Gunnar Voldborg, and Tune Wulff (Abstract)
Regeneron's upstream "Bench of the Future": Automating towards a future of "No Touch" bioreactor sampling, John Czukkermann, Kyle Doce, Shawn Lawrence, Hanne Bak, Frank Ritacco, and Brandon Veres (Abstract)
Enhancing CHO cell productivity through omics technologies and machine learning, Arathi Krishnakumar (Abstract)
Development of a high yield intensified fed-batch process for a CHO-DG44 cell line, Peifeng Chen, Deonte Toliver, Dan Gowetski, Jason Gall, Sean Mack, Atul Agrawal, Cole Whitaker, James Lee, Katherine Okada, and Cathy Kwon (Abstract)
Optimizing recombinant adeno-associated virus production and characterization: assessing physical and functional titer for therapeutic development, Yaxin Yang and Anne Skaja Robinson (Abstract)
Achieving extreme cell densities in perfusion culture: Strategies and challenges, Jongchan Lee, Yawen Tang, Yikun Huang, Michael Borys, Anurag Khetan, and Yashika Singh (Abstract)
Data augmentation models for stem cell bioprocessing, Emmanuel Tzanakakis, Owen Skriloff, and Demetrios Stoukides (Abstract)