Advancing Manufacture of Cell and Gene Therapies IX [2026]

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26 conference - Advancing Manufacture of Cell and Gene Therapies ​IX, John Moscariello, Corinne Hoesli, and Bruno Marques (Article)

 

Advanced therapeutics biomanufacturing in the academic-hospital setting and patient impact, Denis-Claude Roy (Abstract)

 

Engineering scalable platforms for viral and non-viral delivery systems in cell and gene therapy, Amine Kamen (Abstract)

 

Macroscale microfluidic bioreactors: Mitigating scale up risk for viral vectors, Colin Cook, Seonah Kang, Austin Santiago, Anthony Park, Nicholas Scianmarello, Christopher Thanos, Yu-Chong Tai, and Yuman Fong (Abstract)

 

Scalable upstream design: Case studies on scale-up/-down platform development enabling robust and scalable rAAV production, Huize Yan, Adriluz Sanchez Paternina, and Nicholas DePrimo (Abstract)

 

Development of an inducible stable producer cell line for RAAV production, Zhen Qin, Qiang Fu, Yongdan Wang, and Seongkyu Yoon (Abstract)

 

Transcriptomic studies coupled with medium optimization to address the bottleneck in the cellular physiology for rAAV production, Yongdan Wang, Qiang Fu, and Seongkyu Yoon (Abstract)

 

From rare diseases to common conditions: Advancing cell & gene therapy for the next era of medicine, Chris Stevens (Abstract)

 

How bioprocess engineering can shape viral vector manufacturing, Antonio Roldao, Rita Fernandes, Cristina Peixoto, Ricardo J.S. Silva, Sónia Mendes, André Nascimento, Tiago Q. Faria, Ricardo Correia, João P. Mendes, and Ana Sofia Moreira (Abstract)

 

Downstream processing of viral gene therapy vehicles: Towards platform processes, Alois Jungbauer (Abstract)

 

Multimodal chromatography for separation of empty and full AAV, Caryn Heldt, Eduardo Barbieri, and Brandon Gitzlaff (Abstract)

 

A nonviral CRISPR platform for in vivo retinal gene editing: Manufacturing and analytical considerations, Apoorva Ramamurthy, Krishanu Saha, Shaoqin Gong, T. Michael Nork, William Murphy, Kelly Ormond, Bikash R. Pattnaik, Melissa Skala, Shengdar Tsai, Jonathan Watts, Ruixuan Gao, Meha Kabra, Varun Katta, Garret Manquen, John Krutty, Marcela Tabima, Srikumar Sengupta, Pawan Shahi, Nicholas Shinners, Divya Sinha, Piper Rawding, Atish Wagh, Alex Xie, Min Zhu, Song Zhang, and Zhanpeng Zhang (Abstract)

 

Nanoparticle-mediated intratumoral gene editing for improved cancer immunotherapy, Guojun Chen (Abstract)

 

Flexible Integrated Toolkit for Biomanufacturing Infrastructure Technology (FITBIT), Stephen Balakirsky, Bharat Kanwar, Francisco Robles, Jie Xu, Brian Wicker, Jing Li, and Benjamin Joffe (Abstract)

 

Towards industry 4.0: Development of a smart bioprocessing platform integrating real-time monitoring and advanced process control for autologous cell therapy, Vincenzo Di Cerbo; Patrick Statham; Nicola Goddard; Doerte Solle; and Juan Carlos Garcia-Cañaveras, (Abstract)

 

Real-time control of rAAV bioreactors: Implementing PAT for enhanced gene therapy manufacturing, Adriluz Sanchez Paternina, Huize Yan, and Nick DePrimo (Abstract)

 

An end-to-end automated manufacturing platform for supervised & scalable organoid-based tissue-ATMP production, Ioannis Papantoniou (Abstract)

 

Future-ready cell Therapy manufacturing: Lessons from automation and robotics, Daniel Strange (Abstract)

 

Application of an AI-driven autonomous robotic platform to enable cost- effective, scalable, and infrastructure-agnostic manufacturing of cell and gene therapies, Rodney Rietze (Abstract)

 

Intensification of cell and gene therapy manufacturing: Modeling, design, and control, Richard Braatz (Abstract)

 

Defining and characterizing stem cell-derived endocrine cell therapy products: Protocol optimization, raman spectroscopy biomarkers, and analytical strategy for product identity and potency, Diepiriye Iworima, Robert Baker, Cara Ellis, Martha Vardaki, Shreyas Rangan, H. Georg Schulze, Michael Blades, Robin F.B. Turner, James M. Piret, and Timothy J. Kieffer (Abstract)

 

Building product-centric control strategies: Integrating product knowledge and analytical capabilities to achieve product quality, Jaymes Fuller and Chris Wiwi (Abstract)

 

Off-target testing for gene-edited allogeneic CAR T cells, Fuxin Shi, Qianhua Dong, Guowei Fang, Thomas Brieva, Zhaohui Zheng, Joeseph Sherba, Lingling Fan, Monami Chakraborty, and Candace Tang (Abstract)

 

Advancing lentiviral vector characterization using nano flow cytometry for particle-level resolution, Joseph Sieling, Kevin Jhun, and Guowei Fang (Abstract)

 

Intelligent analytics for intelligent cells: Pioneering the future of iPSC therapies, Lindsay Fraser (Abstract)

 

Multiomics platform enabling 2-day QC release and characterization of cell therapy products, Dwight Baker, Shawn Levy, Tierney Bougie, Sophia Espanola, Laura Smith, Isabella Vahrson, Fan Yang, Ekta Dadlani, Saege Hancock, Dave Robbins, Brandon Razooky, and Anne Decker (Abstract)

 

Bridging engineering and biology to accelerate the manufacture of allogeneic cell therapy products, Margarida Serra, Pedro Vicente, Paula M. Alves, Marta H. Costa, Miguel Fuzeta, Beatriz Fazendeiro, Catarina Costa, João Jacinto, Beatriz Painho, Ana Meliciano, and Lara Inocêncio (Abstract)

 

Novel protocol to differentiate human pluripotent stem cell-derived epicardial cells to cardiac pericytes, Fathima Shabnam, Hope Holt, Martha Floy, Yunfeng Ding, Benjamin Gastfriend, and Sean Palecek (Abstract)

 

From bench to bioreactor: Navigating scale-up in iPSC-derived hepatocyte production, Oliver Kraemer, Lauren Jansen, Pratibha Tripathi, Nathalie Chretien, Jeffrey Lee, Ryan Viola, and Chris Ramsborg (Abstract)

 

Applying advanced processing technologies across the iPSC development lifecycle, Lise Munsie (Abstract)

 

Addressing economic challenges in autologous cell therapy via automated and multiplexed closed systems, Behnam Partopour, Lucas Reger, Steven Binninger, David Pollard, and Sunandan Saha (Abstract)

 

Bifunctional antibody–peptide microcarriers enable selective capture and expansion of endothelial colony-forming cells in a vertical-wheel bioreactor, Hugo Level, Marc-Antoine Campeau, Corinne A Hoesli, and Arianna Castro Rojas (Abstract)

 

Engineering the future of CGT manufacturing: Insights from clinical development and commercialization of advanced therapies for oncology and rare disease, Susan Abu-Absi (Abstract)

 

Cost modelling to drive CAR-T cell manufacturing decisions: Cell source and gene transfer approaches, Agnes Julia Aparte, Steffen Schulze, and Suzanne S. Farid (Abstract)

 

Hypoxia-driven modulation of CAR T cell culture in stirred-tank bioreactors maximizes cell expansion and killing efficacy in a solid tumor model, Margarida Costa, Leonor N. Matos, Margarida Serra, Marta H. G. Costa, Ana S. Coroadinha, Gabriela Silva, Hélio Tomás, and Constança M. Costa (Abstract)

 

AI-driven innovation in cell therapy: Celmo And Chemplifytm transforming T Cell manufacturing, Ling Wu, Nicholas Gascoigne, Jie Sun, and Nurul Ainaa Adilah (Abstract)

 

Characterizing the impact of hydrodynamic environments on the expansion of human induced pluripotent stem cell aggregates in computer controlled, clinically relevant-scaled bioreactors, Tiffany Dang, James Kim, Benjamin Turner, Jeff Hou, Sunghoon Jung, Michael S. Kallos, and Breanna S .Borys (Abstract)

 

Overcoming the challenge of scalable fill/finish strategies for cryopreserved allogeneic cell therapies, Katie Pollock, Tracey R Turner, and Taylor Hilton (Abstract)

 

Cell harvest process parameter optimization improves post-thaw quality and functionality in iPSC-derived ab CAR-T cells, Victoria Karakis, Alyssa Suarez, Bruno Marques, and Nayyereh Rajaei (Abstract)

 

Towards non-invasive quality monitoring in the production of stem cell-derived pancreatic islets, Corinne Hoesli, Rohan Singh, Hamid Ebrahimi Orimi, Praveen Kumar Raju Pedabaliyarasimhuni, and Moncef Chioua (Abstract)

 

Remediation of an adenovirus infectious titer release assay to enable reliable QC support for cell and gene therapy products, Adam Haines and Jaymes Fuller (Abstract)

 

Development of complex functional methods to measure and identify virally delivered payloads for Cell and Gene Therapy Products, Henri Estanbouli and Jaymes Fuller (Abstract)

 

PAINT: Targeted high-resolution gene therapy using electrospray and cold plasma, Julia Nelson, Yongsong Huang, James Kurdi, Ravi Kane, and Andrei Fedorov (Abstract)

 

Plasma-induced transient poration enables biomolecule delivery to adherent cells, Yongsong Huang, Julia Nelson, Ayomide Samson Oluwajoba, James Kurdi, Ravi S. Kane, and Andrei G. Fedorov (Abstract)

 

Development of a stable cell manufacturing process based on a novel risk assessment method considering control difficulty, Masahiro Kino-oka (Abstract)

 

Engineering immunocompetent 3D brain cultures for AAV-based gene therapy development, Margarida Serra, Catarina Brito, Paula M Alves, Catarina M Gomes, Gabriela Silva, Mafalda Aleixo, Daniel Simão, Lekh N Dahal, Stephan J Holtkamp, Mark Trautwein, and Bayer Pradeep Harish (Abstract)

 

Defining and characterizing stem cell-derived endocrine cell therapy products: Protocol optimization, Raman spectroscopy biomarkers, and analytical strategy for product identity and potency, Diepiriye Iworima, Robert Baker, Cara Ellis, Martha Vardaki, Shreyas Rangan, H. Georg Schulze, Michael Blades, Robin F.B. Turner, James M. Piret, and Timothy J. Kieffer (Abstract)

 

Alternative flow cytometry assay controls for autologous CAR-T drug products assessment, Wen Xie, Luqing Ren, Guowei Fang, Tom Brieva, Elaine Yang, Zhaohui Zheng, Chuan Wang, and Anqi Li (Abstract)

 

Optimization of isolation and cryopreservation of B cells and impact to cell culture process performance, Kohana Leuba, Alan Gilbert, Sidney Steiner, Marah Mukhtar, Jordan Smelker, and Prasad Gyawali (Abstract)

 

Innovative and GMP-friendly manufacturing process for production of off the shelf allogeneic cell therapy, Joseph Sherba, Lingling Fan, Guowei Fang, Tom Brieva, Zhaohui Zheng, Elaine Yang, Fuxin Shi, Julia Rohlhill, Wen Xie, Jessica Rios Esteves, Lucas Schneider, Elden Swindell, Nadine Lindsay, Monami Chakraborty, Candace Tang, Luqing Ren, Kevin Jhun, David Zurowski, Kinnari Darji, and Christopher Zafonte (Abstract)

 

Bridging development and GMP: Leveraging pilot-scale viral vector production to advance cell therapies, Andrew Gates (Abstract)

 

AAV purification using a next-generation monolithic QA IEX chromatography media, Chervee Ho (Abstract)

 

Control of aggregation and agglomeration during the differentiation of induced pluripotent stem cells, Randall Learish and Sho Sato (Abstract)

 

Functional interrogation of human T cells using the Beacon DiscoveryTM optofluidic system, Joseph Valdez, Patrick Ingram, Qiong Gao, Brandon Bruhn, Bruker Cellular Analysis, Or Gadish, Ritika Kukreja, Julie Perreau, Leqian Liu, Minha Park, Edward Han, and Alireza Salmanzadeh (Abstract)

 

Enzymatically-degradable hydrogel microcarriers modulate effects of pro-inflammatory cytokine licensing of MSCs, Keshav Shah and Johnna Temenoff (Abstract)

 

Standardizing cryopreservation of leukapheresis material to enhance cell therapy quality and supply chain resilience, Schuyler Mesen (Abstract)

 

Advancing allogeneic cancer therapies through integrated manufacturing of γδ T Cells in scalable bioreactors, Margarida Costa, Beatriz Painho, Catarina Costa, Beatriz Fazendeiro, Nádia Duarte, Laura G. Pérez, Víctor M. Díaz, Sergi Casadó, Pablo Menéndez, Stefanos Theoharis, Marta H. G. Costa, and Margarida Serra (Abstract)

 

Dynamics and heterogeneity of cell killing in engineered T-cells revealed by CellCage EnclosuresTM, Shawn Levy, Richard Yau, Shreya Deshmukh, JangKeun Kim, Jiwoon Park, Yanping Yang, Makenzie Sacca, Christopher E. Mason, and Moonsoo M. Jin (Abstract)

 

Directing human pluripotent stem cells to endothelial cells using ETV2-mRNA loaded ionizable lipid nanoparticles, James Rolland, Ellison Emerick, Sydney Erickson, Sean Palecek Ph.D., and William Murphy Ph.D. (Abstract)

 

Scale-up strategies for iPSC-derived T-Cell manufacturing: Influence of vessel size and culture volume on cell phenotype and function, Arina Perez (Abstract)

 

Alignment of processes across clinical trials in different geographies, Zhaohui Zheng, Guowei Fang, and Tom Brieva (Abstract)

 

In-depth cell characterization for advancing cell therapies and manufacturing, Shivaram Selvam, Hazel Y. Stevens, Brian J. Wicker, Johnna S. Temenoff, and Greg Gibson (Abstract)

 

Optimizing closed-system iPSC processes using a scaled-down, computer-controlled parallel bioreactor platform and high-density cell banking, Breanna Borys, Sunghoon Jung, Omokhowa M. Agbojo, Govanni Estrada, and Walongorn Kritalukkul (Abstract)

 

Development of scalable, versatile, and cost-effective processes for iPSC-derived cell therapy manufacturing via linear scale-up (up to 80L) and high-density cell banking approaches, Omokhowa Agbojo, Ethan Feild, Sunghoon Jung, Breanna S. Borys, and Govanni Estrada (Abstract)

 

Investigation of spatial heterogeneity, gene expression and expansion kinetics in pluripotent stem cell aggregates expanded in bioreactors, Erin Roberts, Tala Al-yasiri, Emilie J Gysel, Roman J Krawetz, and Michael S Kallos (Abstract)

 

Towards scalable cell therapy manufacturing: Differentiation of iPSCs into natural killer cells under shaking conditions, Gauri Anil Wali, Steffen Goletz, and Lasse Ebdrup Pedersen (Abstract)

 

Bioprocess development and intensification for billion-scale production of hiPSC-based cell products, Antoniol Roldao, Pedro Vicente, Margarida Serra, Joana Almeida, nês A. Isidro, Ana Louro, Inês Crespo, Nikolaus Virgolin, Ana Meliciano, Cláudia Diniz, João Jacinto, Paula Alves, António Roldão, Lara Inocêncio, Manuel M Mazo Vega, Felipe Prósper, Olalla Iglesias García, Asier Ullate-Agote, Patxi Martin-Uriz, Juan R. Rodriguez-Madoz, Martina Micheletti, Andrea Ducci, and Gonzalo Ríos-Muñoz (Abstract)