Biochemical and Molecular Engineering XXIII: Accelerating Biotech Solutions to aid a Changing World

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24 conference program - Biochemical and Molecular Engineering XXIII: Accelerating Biotech Solutions to aid a Changing World, Michelle O’Malley, Brian Pfleger, and Varnika Roy (Article)

 

How Biotechnology Innovation Drives Benefits to Patients and the Planet: Case Studies from Medicine Design & Manufacturing, Philip Dellorco (Abstract)

 

Optimized manufacturing of Adeno-associated Virus for gene therapy, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Niall Barron, and Brian Glennon (Abstract)

 

Deconstructing synthetic biology: a conceptual approach for training synthetic biologists, Ashty Karim (Abstract)

 

Teaching Old Dogs New Tricks — Elucidating Core Design Principles to Engineer Nonconventional Yeasts and Consortia as Microbial Factories, Zengyi Shao (Abstract)

 

Transferring lab innovation into large scale application by thorough understanding of strains and processes, Ralf Takors (Abstract)

 

Next generation bioproducts: Accelerating the path from innovation to commercialization, Henk Noorman and Cees Haringa (Abstract)

 

Biochemical Engineering: Tales at the Intersection of Technology, Fundamental Research, and Application, Kelvin Lee (Abstract)

 

NRSF plays a central role in controlling µ-opioid receptor, S. Patrick Walton, Christina Chan, and Ryan Thompson (Abstract)

 

Predicting outcomes of cardiac progenitor cell differentiation to cardiomyocytes based on integrated transcriptomics and epigenomics, Sean Palecek (Abstract)

 

Programming cellular sensors with genetic control systems, Laura Segatori (Abstract)

 

Engineering high-precision, dynamic genetic control systems for cellular reprogramming, Katie Galloway (Abstract)

 

Optogenetic intensification of insulin secretion in pancreatic beta-cells for diabetes, Emmanuel Tzanakakis, Zijing Chen, Demetrios Stoukides, and Vishal Ahuja (Abstract)

 

Design of feeder-free processes for natural killer cell expansion, Samira Azarin, edram Motallebnejad, Janani Narayan, Frank Cichocki, and Wei-Shou Hu (Abstract)

 

A Journey Towards the Development of a Cloud Biofoundry, Huimin Zhao (Abstract)

 

Overcoming the Risks in Biochemical Product Development and Manufacturing Through Rapid, Genome Scale Metabolic Engineering, Richard Fox (Abstract)

 

Harnessing genome engineering and automation to engineer next-gen microbial production strains for biologics, Markus Mund (Abstract)

 

Accessible DNA construction from oligonucleotide pools using Golden Gate Assembly and Data-optimized Design, Sean Johnson, Sean Lund, Vladimir Potapov, Jackson Buss, Rey Moncion, and Nathan A Tanner (Abstract)

 

Growing global bioeconomies through perfusion fermentation, Kerry Love (Abstract)

 

Evolution of the Irish Biotechnology Sector, Barry Heavey (Abstract)

 

Hyperstable synthetic miniproteins as developable ligand scaffolds, Benjamin Hackel (Abstract)

 

MAGMA-seq enables wide mutational scanning of human antibody libraries, Tim Whitehead (Abstract)

 

Engineering the Redox Chemistry of Life, Han Li (Abstract)

 

Glycosylation of full-length antibodies in engineered bacteria, Matt DeLisa (Abstract)

 

Engineering enzymes by force: Modulating the catalytic activity of an alcohol dehydrogenase via mechanical forces applied by DNA springs, Scott Banta and Ipek Simay Gokulu (Abstract)

 

Determining membrane protein binding kinetics and stability in nanodiscs for improved drug development, Anne Robinson and John Pettersen (Abstract)

 

Deconstructing and reconstructing polyethylene deconstruction pathways of mealworm gut microbiomes, Mark Blenner (Abstract)

 

Production of supply-limited natural product therapeutics using engineered yeast, Jay Keasling (Abstract)

 

Rebuilding a More Diversified Carbon Economy with Biology, Corrine Scown, Sarah Nordahl, Melissa Moore, Yan Wang, Wilson McNeil, and Nawa R. Baral (Abstract)

 

CRISPR interference libraries for genome scale functional genomics, Carrie Eckert (Abstract)

 

Optogenetic control of protein production in Pichia pastoris replaces methanol induction with light, Jose Avalos, Sebastián Espinel Ríos, Makoto Lalwani, and Shannon M. Hoffman (Abstract)

 

CatPred: A comprehensive framework for deep learning in vitro enzyme kinetic parameters KCAT, KM and KI, Costas D Maranas and Veda Sheersh Boorla (Abstract)

 

The role of cofactor recycling in bacterial organelles for sustainable production of biochemicals, Danielle Tullman-Ercek (Abstract)

 

Unveiling Paclitaxel Biosynthesis: Integrating Engineered Microbial Consortia and Functional Genomics to discover a Crucial Taxane Hydroxylase, Leonardo Rios Solis, Jonitud Nestor, Escrich Ainoa, Malcı Koray, Moyano Elisabeth, Palazon Javier, Sanchez-Muñoz Raul, and Rios-Solis Leonardo (Abstract)

 

Strangers in a Strange Land: Challenges in the study of cellular interactions, Vassily Hatzimanikatis (Abstract)

 

Highly multiplexed design of an allosteric transcription factor to sense novel ligands, Vatsan Raman, Nishikawa KK, A Chen J, Acheson JF, Harbaugh SV, Huss P, Frenkel M, Novy N, Sieran HR, Lodewyk EC, Lee DH, Chavez JL, Fox BG, and Raman S (Abstract)

 

Engineering and Design of Multifunctional Metalloproteinase Inhibitors, Maryam Raeeszadeh-Sarmazdeh (Abstract)

 

Rational design of effective CRISPR-Cas antifungals, Cong Trinh, Christopher Cotter, Jared C. Clements, Xianliang Zheng, and Brian J. Mendoza (Abstract)

 

Bioengineering of cancer stem cells for improved disease modelling, John Kim (Abstract)

 

Unraveling the impact of climate change on Arctic diatom-cyanobacteria symbiosis and the global carbon cycle, Ranjan Srivastava and Joseph Zavorskas (Abstract)

 

Adventures in biomanufacturing: Mixing chemical engineering, systems biology, and metabolic engineering for a fruitful cell culture broth, Mike Betenbaugh (Abstract)

 

Into Darkness: Understanding non-coding regions of the CHO genome, Nicole Borth, Federico DeMarco, Alexander Molin, Ivy-Rose Sebastian, and Antonino Napoleone (Abstract)

 

Reprogramming plant hormone receptors as biosensors and chemically- inducible genetic circuits, Ian Wheeldon, Sean Cutler, and Timothy Whitehead (Abstract)

 

SynBio in the Soil: Tools, Models, and Applications, Natalie Farny (Abstract)

 

Targeted DNA insertion in plants by CRISPR-associated transposons, Gozde Demirer, Yunqing Wang, and Kimberley Muchenje (Abstract)

 

Broadening the BioElectronics Bandwidth: Interesting (hopefully) applications, William Bentley, Sally Wang, Dana Motabar, Chen-Yu Chen, Futoon Al-Jiraf, Rahma Zakaria, Monica Chu, Kayla Chun, Chen-Yu Tsao, and Gregory Payne (Abstract)

 

Hidden Figures: Gut microbes that promise efficient carbon cycling for sustainable biomanufacturing, Kevin Solomon (Abstract)

 

Microbial strain engineering to advance biomanufacturing, Aindrila Mukhopadhyay (Abstract)

 

Trash to Treasure: Converting Nitrogen Pollutants into Industrial Chemicals, Keith Tyo, Kevin Fitzgerald, McKenna Farme, Md Aminul Prodhan, Rashmi Raj, and George Wells (Abstract)

 

Harnessing acetogenic bacteria for sustainable chemical production: a systems and synthetic biology approach, Benjamin Woolston (Abstract)

 

Engineering synthetic anaerobic consortia by division of labour for sustainable biomanufacturing, Christopher Lawson (Abstract)

 

Spatial and temporal control of metabolic pathways for increased biosynthesis in the emerging yeast Kluyveromyces marxianus, Nancy Da Silva (Abstract)

 

Development of recombinant platforms for the upcycling of waste to protein-based biopolymers, Mattheo Koffas (Abstract)

 

Towards sustainable, bio-sourced polymers, Kristala Prather, K’yal R. Bannister, Bradley D. Olsen, and Alex Zappi (Abstract)

 

Engineering Genetic Tools to Control Individual Microbes and Microbiota without Antibiotic Resistance Genes at a Single Strain Level, Tae Seok Moon, Austin G. Rottinghaus, Matthew Amrofell, Steven Vo, Sunaina Rengarajan, and Gautam Dantas (Abstract)

 

Analyzing the potential of toluene \no\n-xylene monooxygenase in drug metabolism via protein engineering, Gonul Vardar-Schara, Noella Younan, Angeline Dauz, Areli Tlatelpa, Felice A Dacpano, and Eli Frazer (Abstract)

 

Cell culture optimization through metabolic modeling and metabolomics in cellular agriculture., Pomaikaimaikalani Yamaguchi, Kirsten Trinidad, Kyongbum Lee, and David Kaplan (Abstract)

 

Advanced manufacturing controls using process analytical technologies (PAT) to enable robust and productive drug substance processes, Kyle McElearney, Sneha Suman, Ronak Gudhka, Michaela Murr, Spencer Holt, Jakob Morris, Harrison Beamer, Namratha Subhash, Tony Wang, Stephanie Kim, Andy Maloney, and Glen Bolton (Abstract)

 

Quantum Mechanical Modeling of Enzyme Promiscuity: Application to Carboligases, Geoffrey Bonnanzio, Linda Broadbelt, and Keith Tyo (Abstract)

 

Engineering synthetic microbial consortia for carbon-efficient waste to chemicals production, Shane Orgnero and Christopher Lawson (Abstract)

 

Influence of Endocytosis on RNA-Containing Complex Activity and Specificity, S. Patrick Walton (Abstract)

 

Unleashing the potential of \nAureobasidium pullulans\n for biosurfactant production by strain and process engineering, Marie R.E. Dielentheis-Frenken, Frederick Haala, Till Tiso, Lars M. Blank, and Philipp Kohl (Abstract)

 

Multichromatic optogenetic control of microbial co-culture populations for chemical production, Jaewan Jang and José L. Avalos (Abstract)

 

Systems biology of isobutanol production in \nSaccharomyces cerevisiae\n reveals a general mechanism to boost chemical production, involving chromatin, mitochondria, and ATP level perturbations, Jose Montano Lopez, Therese Kichuk, Jaewan Jang, Jeremy D. Cortez, and José L. Avalos (Abstract)

 

Closed loop control of microbial population ratio of optogenetically controlled yeast-yeast consortia, Saurabh Malani, Sergio Garcia Echauri, Yannis Kevrekidis, and Jose L Avalos (Abstract)

 

SialMAX: Maximizing Biopharmaceutical α-2,6-Sialylation in CHO Cells, Cristina Abascal Ruiz, Dishon Hiebner, Eoin Casey, and Ioscani Jimenez del Val (Abstract)

 

Accelerated, low ecological footprint, manufacturing platform for continuous production of biotechnological products, Natalia Danielewicz, Florian Simon, Jürgen Mairhofer, Patrick Stargardt, Florian Strobl, Florian Weiss, and Johanna Berein (Abstract)

 

Global Proteomics and Resource Allocation Modeling Reveals Thermodynamic Bottlenecks and Highlights Genetic and Metabolic Interventions for c. Thermocellum, Wheaton Schroeder, Thomas Willis, Daven Khana, Daniel Amador-Noguez, and Costas D. Maranas (Abstract)

 

CatPred: A comprehensive framework for deep learning \nin vitro\n enzyme kinetic parameters k\ncat\n, K\nM\n and K\nI, Veda Sheersh Boorla and Costas D Maranas (Abstract)

 

High-efficiency PET degradation with a two-enzyme system immobilized on magnetic nanoparticles, Qing Sun, Siddhi Kotnis, and Siddhant Gulati (Abstract)

 

Parameterizing large-scale kinetic models using an improved framework, Patrick Suthers, Mengqi Hu, and Costas D. Maranas (Abstract)

 

Bottom-up reconstruction of synthetic pyrenoids unravels the evolution and mechanisms of carbon concentration by EPYC1 peptides, Andreas Markus Küffner, Bianca Pommerenke, Laura Kley, Jediael Zheng Ying Ng, Simone Prinz, Matthias Tinzl-Zechner, Peter Claus, Nicole Paczia, Jan Zarzycki, Matthias Tinzl, Georg Karl Albrecht Hochberg, and Tobias Jürgen Erb (Abstract)

 

Dial-A-Sugar: Developing Actuators for Real-Time mAb Glycosylation Control in CHO Cells, Sheryl Lim, Rajinder Kaur, Apostolos Tsopanoglou, Alfonso Blanco, Sara Carillo, Jonathan Bones, and Ioscani Jiménez del Val (Abstract)

 

Novel high-throughput screens for protein assembly reveal essential molecular interactions in bacterial organelle assembly, Carolyn Mills, Nolan W. Kennedy, and Danielle Tullman-Ercek (Abstract)

 

Acetate availability determines the trade-off between growth and fatty acid chain length in chain-elongating bacteria, Ian Gois, Byung-Chul Kim, Robert Flick, and Christopher Lawson (Abstract)

 

Model-Driven Transfection Process Development, Ana Luiza Pinto Queiroz (Abstract)

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Progressive Protein Engineering for Rapid Discovery of a Detergent Protease with Enhanced Sustainability and Stain Cleaning Benefits, Thomas Graycar (Abstract and Presentation)

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Development of automatic and miniaturised continuous fermentation system for improvement of microbial strains, Krittanai Trisakulwattana, Mario A . Torres-Acosta, Martin Blackman, Marco Cardoso Marques, and Duygu Dikicioglu (Abstract and Presentation)

 

Enhancing the growth capability of a novel industrial biotechnology host, \nHalomonas\n sp. under oxygen limitation, Waritthorn Thanakarn, Mario A. Torres-Acosta, and Duygu Dikicioglu (Abstract)

 

Genome-scale metabolic models for a synthetic soil microbial community as a path for understanding community functioning, Omar Keshk, Evangelia Vayena, Senka Čaušević, Jan Roelof van der Meer, and Vassily Hatzimanikatis (Abstract)

 

Scalable stem cell-based platform to produce tissue specific extracellular vesicles (EVs), Rachel Moen, Gabriella Faircloth, Ethan Lippmann, and Jamey Young (Abstract)

 

Enhancing monoclonal antibody production through targeted metabolic engineering of industrial CHO cells, Kevin Ruiz-Márquez, Lauren Kraft, Michael J. Betenbaugh, and Jamey D. Young (Abstract)

 

Metabolite-regulated CRISPR activation for dynamic transcriptional control, Anthony Stohr, Helena Hansen, Mark Blenner, and Wilfred Chen (Abstract)

 

Polyethylene deconstruction initiated by LDPE-oxidases from yellow mealworm gut microbiota, Ross Klauer, Alex Hansen, Zoé O. G. Schyns, LaShanda T.J. Korley, Kevin V. Solomon, and Mark A. Blenner (Abstract)

 

Developing light-driven energy systems for cell-free protein synthesis, Blake Rasor, Guillaume Bélissent, Markus Meier, Tobias Erb, and João Levandosk (Abstract)

 

Enhancing Human Cell Line Engineering via Cell Line Specific Sequence Alignmnet, Eva Price, Thomas Evans, James Miskin, Kyriacos Mitrophanous, and Duygu Dikicioglu (Abstract)

 

The role of IRE1 under elevated levels of palmitate on DNA damage repair and the development of chemotolerant breast cancer cells, Kevin Chen, Sean Foster, Caleb Sandum, Sardar Mehtab Murtaza, Lainey Gouin, Samantha Zaloudek, Christina Chan, and S. Patrick Walton (Abstract)

 

Engineered viruses meets engineering characterization: facilitating successful recovery of quality lentiviral vectors through process and product understanding, Andrea Rayat, Noor Mujahid, Bart Szafran, Shaleem Isaac Jacob, Deniz Ucan, Giada Mattiuzzo, and Yasu Takeuchi (Abstract)

 

Engineered Enzymes Enable Scalable and Sustainable Nucleic Acid Synthesis, Zhe Rui (Abstract)

 

Altering Degradation Pathways in Cells Under ER Stress Improves Recombinant Protein Production, R. Chauncey Splichal, Christina Chan, and S. Patrick Walton (Abstract)

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Nucleic acid exchange between \nclostridium spp.\n revealed through PacBio sequencing and rRNA-\nfluorescence in situ hybridization, John Hill, Kamil Charubin, and Terry Papoutsakis (Abstract and Presentation)

 

Harnessing syntrophic microbial cocultures for carbon-neutral, supratheoretical isopropanol production, Sofia Capece, Hyeongmin Seo, Noah Willis, John Hill, Eleftherios Papoutsakis, and Jonathan Otten (Abstract)

 

Methanotrophic Culture Adaptation to Build an Efficient Electrobiochemical Carbon Dioxide Valorization Process, Kent Rapp, Richard Hamilton, Hao Shen, Chao Wang, Marina Kalyuzhnaya, and Michael Betenbaugh (Abstract)

 

ADBANCED PRODUCTION OF L-HISTIDINE AND ITS DERIVATIVES USING COSTOMIZED CORYNEBACTERIUM GLUTAMICUM, Sung Ok Han, Jun Won Oh, and Myeong-Eun Lee (Abstract)

 

Tautomer-informed biochemical Reaction Prediction for Pathway Design, Konrad Lagoda, Anastasia Sveshnikova, Jasmin Hafner, and Vassily Hatzimanikatis (Abstract)

 

In silico functional comparison of the leaf microbiome by reducing metabolic complexity, Evangelia Vayena, Alan R. Pacheco, Julia A. Vorholt, and Vassily Hatzimanikatis (Abstract)

 

Genetic basis of dicarboxylic acid metabolism in four \nβ\n-proteobacteria, Allison Pearson, Julie M. Lynch, Cindy N. Ho, Mitchell G. Thompson, Adam M. Deutschbauer, and Jay D. Keasling (Abstract)

 

Engineering Autonucleolytic Host Cells for Improved Bioprocessing of Gene Therapy Viral Vectors, Darren Nesbeth, Geoffrey . Howe, and Sadfer Ali (Abstract)

 

Robust cyanophycin production critically limited by lackluster enzyme expression and native regulatory networks, Kevin Fitzgerald and Keith E.J. Tyo (Abstract)

 

Engineering Nitrogen-Fixing Bacteria for Agricultural Use, Maya Venkataraman (Abstract)